Recombinant Bovine Bifunctional Methylenetetrahydrofolate Dehydrogenase/Cyclohydrolase, Mitochondrial (MTHFD2), N-His-SUMO

Bovine bifunctional methylenetetrahydrofolate dehydrogenase (MTHFD) is a crucial enzyme involved in one-carbon metabolism, which is essential for the synthesis of nucleotides, amino acids, and the methylation of DNA and proteins. This enzyme catalyzes the interconversion of 5,10-methylenetetrahydrofolate (THF) to 5,10-methenyl-THF and subsequently to 10-formyl-THF, providing formyl groups for the de novo synthesis of purines and thymidine. In cattle, MTHFD plays a vital role in cellular proliferation, embryonic development, and the maintenance of epigenetic marks. It also contributes to the regulation of the cell cycle and may have implications in the development of cancer. The study of MTHFD in Bovines can provide insights into metabolic pathways and their impact on overall health and disease susceptibility in cattle.