Mouse Anti-Canine Apoptosis-Inducing Factor Mitochondrion-Associated 1 (AIF) Monoclonal Antibody

Canine apoptosis-inducing factor, mitochondrion-associated 1 (cAIFM1) is a protein found in dogs that is associated with the mitochondria and plays a pivotal role in the regulation of apoptosis, or programmed cell death. cAIFM1 is a flavoprotein that, when released from the mitochondria in response to certain cellular stressors, can induce chromatin condensation and large-scale DNA fragmentation, which are characteristic features of apoptosis. This protein is part of the intrinsic apoptotic pathway, which is activated by various cellular stress signals such as DNA damage, oxidative stress, and the activation of cell surface death receptors. Under normal conditions, cAIFM1 is located in the intermembrane space of the mitochondria. However, during apoptosis, it translocates to the nucleus to execute cell death.