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Mouse Anti-Canine Ran GTPase Activating Protein 1 (RANGAP1) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine ran GTPase activating protein 1. It can be applied to WB, ICC/IF, IHC and FACS assays of canine ran GTPase activating protein 1.
Specifications
Target Information
Canine ran GTPase activating protein 1 (RANGAP1) is a protein that associates with the nuclear pore complex and plays a pivotal role in the regulation of nuclear transport. It interacts with the Ras-related nuclear protein 1 (RAN), modulating guanosine triphosphate (GTP) binding and exchange, which are crucial for nucleocytoplasmic transport, mitotic spindle formation, nuclear envelope assembly, and heterochromatin assembly. This protein is also implicated in chromosome stability and tumorigenesis, as loss of RANGAP1 can drive chromosome instability and rapid tumorigenesis of osteosarcoma. Targeting RANGAP1 may offer therapeutic strategies for aggressive B-cell lymphoma, highlighting its significance as a potential therapeutic target in canine oncology.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.