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Mouse Anti-Canine Transcription Factor IIB (TFIIH) p89 Monoclonal Antibody

Cat. No.VD8N171

Product TypeAnimal-targeted Antibodies

Size

Product Overview

BioVenic mouse monoclonal antibody is specific for canine transcription factor IIB p89. It can be applied to WB assay of canine transcription factor IIB p89.

Specifications

Application WB
Clonality Monoclonal
Classification Primary Antibody
Clone G4N34
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Transcription Factor IIB p89
Isotype IgG
Immunogen Purified recombinant canine transcription factor IIB p89 (C-terminus) protein fragments
Concentration 1 mg/mL
Conjugation Unconjugated
Physical State Liquid

Target Information

Transcription factor IIB p89 (TFIIB p89), also referred to as the small subunit of TFIIB, is a component of the transcription factor IIB complex that is indispensable for the initiation of transcription by RNA polymerase II. This protein plays a critical role in the formation of the pre-initiation complex, interacting with the TATA-binding protein (TBP) and DNA to stabilize the binding of RNA polymerase II to the promoter region. TFIIB p89 contributes to the recognition of the transcription start site and is involved in the opening of the DNA double helix, allowing the polymerase to begin transcription. Its function is essential for the regulation of gene expression across a variety of cellular processes, including cell cycle progression, development, and response to stress.

Target Canine Transcription Factor IIB p89
Target Synonym ERCC3; XPB
Gene ID 476105
UniProt ID A0A8C0P8L8

Shipping and Storage

This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Baek, Hwa Jin, et al. "Human Mediator enhances basal transcription by facilitating recruitment of transcription factor IIB during preinitiation complex assembly." Journal of Biological Chemistry 281.22 (2006): 15172-15181.
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