Mouse Anti-Hendra and Nipah Virus Glycoprotein Monoclonal Antibody

The glycoprotein of hendra and nipah viruses, known as G, is a critical surface protein that plays a pivotal role in the viral attachment and fusion with host cells. This glycoprotein is responsible for the initial interaction with host receptors, allowing the virus to enter and infect target cells. The G protein is also a major antigenic determinant, eliciting a strong immune response, which makes it a prime target for vaccine development. The G protein of Hendra and Nipah viruses is a type I transmembrane glycoprotein that undergoes post-translational cleavage to generate two subunits: G1 and G2. The G1 subunit is involved in receptor binding, while the G2 subunit mediates membrane fusion. The structural and functional characterization of the G protein is essential for understanding the molecular mechanisms of viral entry and pathogenesis.