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Mouse Anti-Porcine Myosin Light Chain 2 (MLC-2V) Monoclonal Antibody

Cat. No.VD8N283

Product TypeAnimal-targeted Antibodies

Size

Product Overview

BioVenic mouse monoclonal antibody is specific for myosin light chain 2. It is affinity purified by protein A. It can be applied to WB, IF, IHC and ELISA assays of myosin light chain 2.

Specifications

Application WB; IF; IHC; ELISA
Clonality Monoclonal
Classification Primary Antibody
Clone G6N27
Host Mouse
Target Species Porcine
Species Reactivity Porcine
Specificity Myosin Light Chain 2
Isotype IgG1
Immunogen Recombinant protein of myosin light chain 2
Purification Protein A Purified
Concentration 1500 μg/mL
Conjugation Unconjugated
Preservative and Stabilizer 0.02% Sodium Azide
Buffer Phosphate Buffered Saline with 50% Glycerol, pH 7.3
Physical State Liquid

Target Information

Porcine myosin light chain 2 (MLC2) is a pivotal component of the myosin molecule, which is essential for muscle contraction in pigs. Myosin, a motor protein, forms part of the thick filaments in muscle fibers and interacts with actin to generate force and movement. MLC2, specifically, is one of the light chains that associate with the myosin heavy chain, contributing to the proper assembly and function of the myosin head, which is responsible for the motor activity. This regulatory light chain plays a critical role in the calcium-dependent activation of the myosin ATPase, which is a key step in the cross-bridge cycling that leads to muscle contraction. MLC2 is subject to phosphorylation, a modification that can increase the ATPase activity of myosin and enhance the force of contraction.

Target Myosin Light Chain 2
Target Synonym CMH10; MLC 2
Gene ID 396690
UniProt ID Q8MHY0

Shipping and Storage

This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Sanbe, Atsushi, et al. "Abnormal cardiac structure and function in mice expressing nonphosphorylatable cardiac regulatory myosin light chain 2." Journal of Biological Chemistry 274.30 (1999): 21085-21094.
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