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Rabbit Anti-Borrelia burgdorferi DbpA Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for Borrelia burgdorferi DbpA. It is affinity purified by protein A. It can be applied to ELISA and WB of Borrelia burgdorferi DbpA.
Specifications
Target Information
Borrelia burgdorferi DbpA, or decorin-binding protein A, is a surface lipoprotein that plays a significant role in the bacterium's pathogenesis and host interaction. DbpA is expressed during the tick phase of the bacterium's life cycle and is involved in the initial attachment of Borrelia burgdorferi to the tick vector and subsequent transmission to the mammalian host. This protein has the ability to bind decorin, a component of the extracellular matrix, which is crucial for the bacterium's adherence to tick tissues and its traversal through the tick's gut. DbpA's interaction with decorin also helps the bacterium to avoid the host's immune response, contributing to its stealth within the host.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Brown, Eric L., et al. "Adherence of Borrelia burgdorferi: identification of critical lysine residues in DbpA required for decorin binding." Journal of Biological Chemistry 274.37 (1999): 26272-26278.