Recombinant Bovine Angiotensin-Converting Enzyme (ACE), N-His

Bovine angiotensin I converting enzyme (ACE) is a key enzyme in the renin-angiotensin system that regulates blood pressure in cattle. It catalyzes the conversion of angiotensin I to the potent vasoconstrictor angiotensin II and degrades the vasodilator bradykinin. This dual action leads to an increase in blood pressure. ACE is a zinc-dependent metallopeptidase with two homologous domains, the N-domain and the C-domain, each containing an active center. The C-domain is considered the dominant site for angiotensin I conversion and is crucial for blood pressure control and cardiovascular function. Inhibition of ACE is a therapeutic strategy for hypertension, and Bovine ACE has been a subject of research for developing natural ACE-inhibitory peptides from food sources like milk, which can serve as alternatives to synthetic ACE inhibitors with fewer side effects.