Mouse Anti-Canine Glucagon Monoclonal Antibody

Canine glucagon is a peptide hormone secreted by the α cells of the pancreas, playing a critical role in glucose homeostasis by stimulating gluconeogenesis, glycogenolysis, and lipolysis. It has opposing effects to insulin and is essential for managing hypoglycemic episodes, particularly in cases of insulinomas. Glucagon also influences the secretion of other pancreatic hormones, such as insulin, and is involved in the counterbalancing of blood sugar levels. In veterinary medicine, glucagon is used as a second-line treatment for refractory hypoglycemia and in cases of insulin overdose. Its role in regulating metabolic pathways across various cell types, including its impact on renal tubular cells, makes it a significant target for therapeutic interventions in canine metabolic and gastrointestinal conditions.