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Mouse Anti-Canine Noggin Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine noggin. It can be applied to WB, ICC/IF and IHC assays of canine noggin.
Specifications
Target Information
Canine noggin (NOG) is a key regulator of bone morphogenetic proteins (BMPs) and plays a significant role in embryonic development, particularly in dorsal induction and joint formation by inhibiting BMP signaling. It is also involved in the control of bone regeneration and homeostasis in adult dogs. In the canine genome, the NOG gene is a potential candidate for involvement in congenital skeletal malformations, similar to its role in humans where mutations have been linked to conditions like proximal symphalangism or multiple synostoses syndrome. This extracellular antagonist's function in BMP signaling makes Noggin a crucial target for understanding and potentially treating skeletal abnormalities in dogs.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Wilcox, Jared T., et al. "Synaptically-competent neurons derived from canine embryonic stem cells by lineage selection with EGF and Noggin." PLoS One 6.5 (2011): e19768.