This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Rabbit Anti-Porcine Transferrin Receptor Protein 1 (TFRC) Polyclonal Antibody-[Biotin]
Product Overview
BioVenic rabbit polyclonal antibody is specific for porcine transferrin receptor protein 1. It is antigen affinity purified. It can be applied to WB, IHC and IF/ICC assays of porcine transferrin receptor protein 1.
Specifications
Target Information
Porcine transferrin receptor protein 1 (TfR1) is a crucial receptor that plays a significant role in the entry of transmissible gastroenteritis virus (TGEV) into porcine intestinal epithelium. Highly expressed in piglets with anemia, TfR1 may be involved in TGEV infection, contributing to the high susceptibility of newborn pigs to the virus. The virus promotes TfR1 internalization and clustering, and its expression is down-regulated as TGEV infection proceeds. Inhibition of TfR1 with antibodies or by decreasing its expression can inhibit TGEV infection and replication, indicating that TfR1 serves as a receptor for TGEV, contributing specifically to virion binding and endocytosis, and determining TGEV tropism.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Zhang, Shuai, et al. "Transferrin receptor 1 levels at the cell surface influence the susceptibility of newborn piglets to PEDV infection." PLoS Pathogens 16.7 (2020): e1008682.