Mouse Anti-Porcine LanC Lantibiotic Synthetase Component C-Like 1 (LANCL1) Monoclonal Antibody

Porcine lanC lantibiotic synthetase component C-like 1 (LanCL1) is an enzyme with significant biological functions. It is involved in the biosynthesis of lanthionine-containing peptides, which are known for their antibiotic, anti-inflammatory, and anti-viral activities. LanCL1 is part of a new class of lanthionine synthetases, termed LanL, that installs dehydroamino acids via phosphorylation of Ser/Thr residues by a protein kinase domain and subsequent elimination of the phosphate by a phosphoSer/Thr lyase domain. A LanC-like cyclase domain then catalyzes the addition of Cys residues to the dehydro amino acids to form the characteristic thioether rings. This enzyme is also involved in the regulation of neuron apoptotic process and oxidative stress-induced neuron death, suggesting its role in cellular redox homeostasis and neuronal survival. LanCL1 is highly expressed in testis and brain, which may hint at a role in the immune surveillance of these organs. Its function is crucial for the development and repair processes of neurons, and it is involved in neural activity, neuroplasticity, and oxidative stress response.