Mouse Anti-Chicken Protein Kinase C and Casein Kinase Substrate In Neurons 1 (PACSIN1) Monoclonal Antibody

Chicken protein kinase C and casein kinase substrate in neurons 1 (PACSIN1), also known as syndapin, is a protein that plays a pivotal role in the regulation of cell cytoskeleton, intracellular trafficking, and signaling. Over the last two decades, PACSINs have been primarily studied in vitro and ex vivo, with in vivo functions emerging in the last decade. In chickens, PACSIN1 is involved in various developmental processes such as neural crest cell development, gastrulation, laterality development, and neuromuscular junction formation. It has been extensively studied in the brain, where it regulates neuromorphogenesis, receptor trafficking, and synaptic plasticity. Genetic studies suggest a role for PACSIN1 in the development of neurological disorders, including schizophrenia, which is supported by the phenotype of mice depleted of PACSIN1.