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Mouse Anti-Porcine Huntingtin-Interacting Protein (HIP) Monoclonal Antibody

Cat. No.VD8N83

Product TypeAnimal-targeted Antibodies

Size

Product Overview

BioVenic mouse monoclonal antibody is specific for porcine huntingtin-interacting protein. It can be applied to WB, IHC, IF and ICC assays of porcine huntingtin-interacting protein.

Specifications

Application WB; IHC; IF; ICC
Clonality Monoclonal
Classification Primary Antibody
Clone G3N47
Host Mouse
Target Species Porcine
Species Reactivity Porcine
Specificity Porcine Huntingtin-Interacting Protein
Isotype IgG
Immunogen Purified recombinant porcine huntingtin-interacting protein fragments
Concentration 1 mg/mL
Conjugation Unconjugated
Physical State Liquid

Target Information

HIP, also known as huntingtin-interacting protein, is a multifunctional protein that plays a significant role in various cellular processes, including endocytosis, protein trafficking, and signal transduction. It is highly conserved across species and is characterized by its ability to interact with a wide range of binding partners, including the protein huntingtin, which is associated with huntington's disease. The interaction of HIP with huntingtin is particularly important, as it is believed to modulate the aggregation and clearance of mutant huntingtin proteins, which are implicated in the pathogenesis of Huntington's disease. Additionally, HIP has been implicated in the regulation of cell cycle progression and apoptosis, further highlighting its importance in maintaining cellular homeostasis.

Target Porcine Huntingtin-Interacting Protein
Target Synonym ST13; AAG2
Gene ID 100523598
UniProt ID A0A8W4FBQ5

Shipping and Storage

This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Hackam, Abigail S., et al. "Huntingtin interacting protein 1 induces apoptosis via a novel caspase-dependent death effector domain." Journal of Biological Chemistry 275.52 (2000): 41299-41308.
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