Mouse Anti-Bovine Coronavirus (BCoV) Spike Protein Monoclonal Antibody

Bovine coronavirus (BCoV) is a significant pathogen affecting cattle, leading to diseases such as winter dysentery and respiratory infections. The virus's spike (S) glycoprotein is a critical target for vaccine development and therapeutic interventions due to its role in host cell attachment and membrane fusion. The S protein's receptor-binding domain (RBD) is particularly important as it determines the specificity for host receptors. Another key target is the nucleocapsid protein (N), which is essential for viral RNA packaging and is highly conserved among coronaviruses, making it a potential target for broad-spectrum diagnostics and vaccines. The membrane (M) protein, involved in virus assembly and release, is also a candidate for antiviral strategies.