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Mouse Anti-Canine Calsequestrin Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine calsequestrin. It can be applied to WB, ICC/IF, IHC and IP assays of canine calsequestrin.
Specifications
Target Information
Canine calsequestrin is the predominant Ca2+-binding protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It serves as the main Ca2+ storage and buffering protein, playing a critical role in the regulation of Ca2+ release channels in both muscle types. This protein allows for the storage of Ca2+ at high concentrations while maintaining a low free Ca2+ concentration, which is essential for muscle contraction and relaxation. Calsequestrin is highly acidic, containing up to 50 Ca2+-binding sites, and its binding affinity for Ca2+ is relatively low but allows for high-capacity storage.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Scott, B. T., et al. "Complete amino acid sequence of canine cardiac calsequestrin deduced by cDNA cloning." Journal of Biological Chemistry 263.18 (1988): 8958-8964.