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Mouse Anti-Canine Calsequestrin Monoclonal Antibody

Cat. No.VD11N141

Product TypeAnimal-targeted Antibodies

Size 100 μL

Product Overview

BioVenic mouse monoclonal antibody is specific for canine calsequestrin. It can be applied to WB, ICC/IF, IHC and IP assays of canine calsequestrin.

Specifications

Application WB; ICC/IF; IHC; IP
Clonality Monoclonal
Classification Primary Antibody
Clone S14N4
Host Mouse
Target Species Canine
Species Reactivity Canine
Specificity Canine Calsequestrin
Isotype IgG2
Immunogen Recombinant protein of calsequestrin
Conjugation Unconjugated
Preservative and Stabilizer 0.05% Sodium Azide
Buffer Phosphate Buffered Saline
Physical State Liquid

Target Information

Canine calsequestrin is the predominant Ca2+-binding protein in the sarcoplasmic reticulum (SR) of skeletal and cardiac muscle. It serves as the main Ca2+ storage and buffering protein, playing a critical role in the regulation of Ca2+ release channels in both muscle types. This protein allows for the storage of Ca2+ at high concentrations while maintaining a low free Ca2+ concentration, which is essential for muscle contraction and relaxation. Calsequestrin is highly acidic, containing up to 50 Ca2+-binding sites, and its binding affinity for Ca2+ is relatively low but allows for high-capacity storage.

Target Canine Calsequestrin
Target Synonym CASQ2
UniProt ID A0A8C0S9Z2

Shipping and Storage

This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.

Documents

COA

To request a Certificate of Analysis, please enter the Lot No. in the search box. Note: Certificate of Analysis not available for kits.

The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.

References

  1. Scott, B. T., et al. "Complete amino acid sequence of canine cardiac calsequestrin deduced by cDNA cloning." Journal of Biological Chemistry 263.18 (1988): 8958-8964.
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