Mouse Anti-Canine Transportin 1 Monoclonal Antibody

Canine transportin 1 is a nuclear import receptor that plays a significant role in nucleo-cytoplasmic transport, particularly in the shuttling of proteins between the nucleus and the cytoplasm. It is involved in the regulation of various cellular processes, including gene expression and signal transduction. Transportin 1 mediates the nuclear import of specific proteins that carry a nuclear localization signal (NLS), such as the nitric oxide synthase interacting protein (NOSIP), which is implicated in neuronal development and cell proliferation. This receptor's function in nuclear transport is crucial for maintaining cellular homeostasis, and its role in the regulation of proteins like NOSIP suggests that it could be a potential target for therapeutic interventions in diseases involving nuclear transport dysregulation in dogs.