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Mouse Anti-Porcine Amyloid Precursor Protein (APP) Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for amyloid precursor protein. It is affinity purified by protein A. It can be applied to WB, IHC and ELISA assays of amyloid precursor protein.
Specifications
Target Information
Porcine amyloid precursor protein (pAPP) is a transmembrane protein found in pigs that is implicated in the regulation of various cellular processes, including cell adhesion, migration, and synaptic function. It is a key molecule in the pathogenesis of neurodegenerative disorders, particularly Alzheimer's disease, due to its role in the production of amyloid-beta peptides, which can aggregate to form amyloid plaques in the brain. pAPP undergoes proteolytic cleavage by enzymes known as secretases, leading to the generation of different fragments. The amyloidogenic pathway results in the formation of amyloid-beta peptides, while the non-amyloidogenic pathway produces soluble APP fragments that may have neuroprotective functions.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Thinakaran, Gopal, et al. "Amyloid precursor protein trafficking, processing, and function." Journal of Biological Chemistry 283.44 (2008): 29615-29619.