Mouse Anti-Porcine G Protein O Polypeptide (GNAO1) Monoclonal Antibody

Porcine G protein O polypeptide (GNAO1) is a subunit of the heterotrimeric G protein, which is essential for signal transduction across the cell membrane. This protein is highly expressed in the central nervous system and plays a crucial role in neural circuit formation. GNAO1 is particularly important for the development and function of neurons, as it is enriched at the tip of the growth cone, a dynamic structure that guides neurite extension and retraction to establish functional connectivity with adjacent neurons. In pigs, GNAO1 may serve as a significant factor in neurodevelopment and could be implicated in the resilience to stress-induced memory deficits. The protein's regulation of Rho GTPase signaling pathways, which are crucial for cytoskeletal remodeling and neuronal connectivity, positions GNAO1 as a potential therapeutic target for neurodegenerative diseases and conditions where neuronal connectivity is compromised.