Mouse Anti-Porcine Lactate Dehydrogenase A (LDHA) Monoclonal Antibody

Porcine lactate dehydrogenase A (pLDHA) is a key enzyme involved in the anaerobic metabolism of lactate in pigs. It is one of the two subunits of the lactate dehydrogenase (LDH) tetramer, the other being lactate dehydrogenase B (LDHB). pLDHA is particularly important for the conversion of pyruvate to lactate during glycolysis, a process that is critical for energy production under oxygen-deficient conditions. This enzyme is expressed in various tissues, including skeletal and cardiac muscle, where it plays a significant role in maintaining energy homeostasis during periods of high metabolic demand or hypoxia. The LDHA isoform is known to be more active in the conversion of pyruvate to lactate compared to LDHB, making pLDHA a crucial factor in the Warburg effect, which is commonly observed in cancer cells.