Mouse Anti-Vaccinia Virus A27 Monoclonal Antibody

The vaccinia virus protein A27, designated as A27L, is a key enzyme within the vaccinia virus, which is a complex DNA virus known for its role as a vaccine against smallpox. A27L is a type I interferon (IFN) receptor that can bind to human IFN-α and IFN-β, thereby neutralizing the antiviral effects of these cytokines. This protein's ability to counteract the host's immune response is a critical factor in the virus's pathogenesis and contributes to its evasion of the host's innate defenses. As a target for antiviral development, A27L presents a unique opportunity. Inhibiting its function could restore the host's interferon response, potentially leading to a more effective immune clearance of the virus. The study of A27L's structure and mechanism of action is vital for understanding the vaccinia virus's immune evasion strategies and could inform the design of new therapeutics to combat poxvirus infections, including those that might be engineered for bioterrorism or biowarfare.