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Mouse Anti-Canine Fumarate Hydratase Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine fumarate hydratase. It can be applied to WB, ICC/IF, IHC and FACS assays of canine fumarate hydratase.
Specifications
Target Information
Canine fumarate hydratase (FH) is an essential enzyme involved in the tricarboxylic acid (TCA) cycle, catalyzing the hydration of fumarate to malate. It plays a critical role in cellular metabolism and energy production within mitochondria. FH deficiency is associated with various metabolic disorders, including hereditary leiomyomatosis and renal cell cancer (HLRCC), characterized by benign tumors and aggressive renal cancer. In addition to its metabolic functions, FH has been identified as a tumor suppressor, and its loss can lead to the accumulation of fumarate, which may activate oncogenic pathways. Understanding FH's role in dogs can provide insights into its implications in metabolic health and cancer biology.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.