This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
Animal Immune Cell Engineering
The animal immune system and immune-related metabolic reactions play a crucial role in the defense against disease and serve as the first line of defense for the animal body. Numerous immune cells work together to maintain the dynamic balance of the immune system. With the advancement of companion animal immune cell therapy and antibody therapy, the engineering of animal immune cells has become a new focus of research. BioVenic has introduced personalized solutions for immune cell modification, leveraging its extensive development in various cutting-edge technologies and advanced platforms in the field of cell biology. Our immune cell engineering solutions focus on KO to reduce immunogenicity, metabolic reprogramming, induced expression and cell hybridization of animal immune cells. We are committed to addressing the many challenges in scientific research initiatives and cell therapy research.
Fig. 1 TCRs vs CAR and genetically modified T cells in immunotherapy.1,2
Animal Immune Cell Gene Modification
To facilitate the application of animal immune cells, BioVenic has established a comprehensive customized gene modification service. Our team of experts divides the genetic modification of immune cells into two main parts. The first part involves modifying T cells to enable them to recognize and efficiently eliminate target cells, with the aim of treating tumors. This process aims to produce T cells that are able to target specific antigens. The second part focuses on reducing the immunogenicity of immune cells by knocking out relevant genes. This approach helps prolong the survival of effective cells in the body and increases the efficacy of immunotherapy. We have a comprehensive animal genome editing technology platform to ensure seamless execution of project plans and reliable results.
Animal Immune Cell Metabolism and Reprogramming
BioVenic provides scientific research services focusing on the metabolic activities and reprogramming of animal immune cells. This enables clients to improve their understanding of the metabolic mechanisms of immune cells and their relationship to function. The activation of animal immune cells requires a large amount of energy and metabolic intermediates to meet the needs of biosynthesis, proliferation, differentiation and effector function. Their metabolic pattern is completely different from that of non-activated immune cells. At the same time, the phenotype and function of immune cells are also regulated by metabolism. We support the exploration of immune cell metabolic pathways through cell metabolomics research and aim to achieve significant breakthroughs in the study of immune cell growth, differentiation, and functional regulation in different metabolic pathways.
Functions and Main Energy Metabolism of Animal Immune Cells
| Cells | Type | Main Metabolic Pathways | Functions |
| Macrophages | Type M1 |
Glycolysis Pentose phosphate pathway |
Secrete anti-inflammatory factors Kill microorganisms |
| Type M2 |
Oxidative phosphorylation Fatty acid oxidation |
Secrete anti-inflammatory factors Immunosuppression and tissue repair |
|
| Dendritic Cells | Quiet DC |
Oxidative phosphorylation Glycolysis |
Antigen presentation and activation of T cell immune response |
| Active DC | Fatty acid oxidation | Antigen presentation and activation of T cell immune response | |
| T Lymphocytes | Effector T cells |
Oxidative phosphorylation Glycolysis |
Secrete lymphokines and perform cell-mediated immunity |
| Memory T cells |
Oxidative phosphorylation Fatty acid oxidation |
Rapid activation of immune response upon secondary invasion of antigen | |
| Neutrophils | / | Glycolysis | Phagocytosis |
| B Lymphocytes | / | Glycolysis | Secretes antibodies to perform humoral immunity |
Why Choose Us?
One-stop service solves various scientific research problems in engineered immune cell projects.
The joint use of multi-directional technology platforms ensures the smooth implementation of experimental designs.
Experienced technicians and strict quality control ensure the quality of service and delivery.
As an expert in the field of animal cells, BioVenic has extensive experience in immune cell development projects and is committed to ensuring that customers' immune cell engineering research progresses smoothly. We combine animal genome editing technology with animal cell metabolomics technology to easily detect, analyze, and modify immune cells based on the personalized project needs of customers. This promotes their application in cell therapy related research. If you are interested in animal immune cell engineering solutions, please feel free to contact us.
References
- Image retrieved from Figure 3 "TCRs vs CAR and genetically modified T cells in immunotherapy" Zhao et al., 2021, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). Without modification.
- Zhao, Qijie et al. "Engineered TCR-T Cell Immunotherapy in Anticancer Precision Medicine: Pros and Cons." Frontiers in immunology vol. 12 658753. 30 Mar. 2021.