Mouse Anti-Canine Retinol Dehydrogenase 11 (RDH11) Monoclonal Antibody

Canine retinol dehydrogenase 11 (RDH11) is a microsomal short-chain dehydrogenase/reductase enzyme that recognizes all-trans and cis-retinoids as substrates and prefers NADPH as a cofactor. It plays a significant role in the visual cycle and the metabolism of vitamin A, particularly in the conversion of retinaldehyde to retinol. RDH11 is essential for maintaining retinol homeostasis in the liver and testis, especially under conditions of reduced vitamin A availability. Its function in extraocular tissues and embryos is also being studied, with recent findings indicating that RDH11 contributes to the maintenance of retinol levels under vitamin A deficiency or reduced vitamin A utilization. The enzyme's activity and regulation are crucial for understanding canine vitamin A metabolism and could have implications for managing related health conditions in dogs.