Rabbit Anti-Borrelia burgdorferi CRASP-1 Polyclonal Antibody

The Borrelia burgdorferi CRASP-1 (Complement Regulator-Acquiring Surface Protein 1), also known as BBK32 or OspE/F, is a pivotal surface protein of the bacterium Borrelia burgdorferi, a spirochete that causes Lyme disease. CRASP-1 is a member of the Erp (OspE/F-related protein) family, which is known for its role in the bacterium's ability to evade the host's immune system. This protein is expressed during the tick phase of the bacterium's life cycle and is involved in the acquisition of host complement regulators, such as factor H and FHL-1, which help the pathogen resist complement-mediated killing. By binding to these complement regulators, CRASP-1 aids in the survival of Borrelia burgdorferi in the host by dampening the host's innate immune response.