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Rabbit Anti-Borrelia burgdorferi CRASP-1 Polyclonal Antibody
Product Overview
BioVenic rabbit polyclonal antibody is specific for Borrelia burgdorferi CRASP-1. It is affinity purified by protein A. It can be applied to ELISA and WB of Borrelia burgdorferi CRASP-1.
Specifications
Target Information
The Borrelia burgdorferi CRASP-1 (Complement Regulator-Acquiring Surface Protein 1), also known as BBK32 or OspE/F, is a pivotal surface protein of the bacterium Borrelia burgdorferi, a spirochete that causes Lyme disease. CRASP-1 is a member of the Erp (OspE/F-related protein) family, which is known for its role in the bacterium's ability to evade the host's immune system. This protein is expressed during the tick phase of the bacterium's life cycle and is involved in the acquisition of host complement regulators, such as factor H and FHL-1, which help the pathogen resist complement-mediated killing. By binding to these complement regulators, CRASP-1 aids in the survival of Borrelia burgdorferi in the host by dampening the host's innate immune response.
Shipping and Storage
This product is shipped with ice gel packs. Store at -20°C (up to 12 months) on receipt. Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.
References
- Siegel, Corinna, et al. "Complement factor H-related proteins CFHR2 and CFHR5 represent novel ligands for the infection-associated CRASP proteins of Borrelia burgdorferi." Plos one 5.10 (2010): e13519.