Veterinary Natural Killer Cell (NK) Therapy Development

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Veterinary Natural Killer Cell (NK) Therapy Development

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Advantages of Veterinary NK Cell CAR Therapy NK Cell Separation and Expansion NK Cell Phenotyping and Identification NK Cell Transformation NK Cell Functional Testing Why Choose Us?

Natural killer (NK) cells are a crucial component of the innate immune system in animals, possessing the ability to recognize and eliminate tumor cells and virus-infected cells without the need for antibodies or major histocompatibility complex (MHC) molecules. In recent years, NK cell therapy has demonstrated significant potential in the treatment of tumors and infectious diseases during the development of immunotherapy, owing to its non-specific cytotoxicity and low risk of immune rejection. BioVenic's customized services for the development of veterinary NK cell therapy focus on advancing immune cell therapy at the research stage, to provide researchers with efficient, safe, and feasible designs for new treatment plans. Through our state-of-the-art technology platform and expert research and development team, we offer comprehensive services to facilitate the innovation and application of veterinary NK cell therapy.

Fig.1 Adoptive NK cell therapy. (Kisseberth, et al., 2021) Fig.1 Generation of ex vivo Expanded Canine NK Cells for Adoptive Immunotherapy.^1,2

Advantages of Veterinary NK Cell CAR Therapy

Minimizing the Risk of Graft-versus-Host Disease (GVHD)	CAR-T cell therapy may lead to graft-versus-host disease (GVHD), which occurs when the host's immune system attacks the transplanted cells. NK cells do not contribute to the development of this disease.
Wide Range of Cell Sources	Natural killer (NK) cells can be sourced from external donors and can be preserved for indefinite use. CAR-T cells typically need to be extracted from the affected animal and expanded in vitro.
Rapid Response and Immediate Function	Natural killer (NK) cells can rapidly recognize and attack target cells without the need for prolonged interaction with antigen-presenting cells (APCs), thereby swiftly initiating an immune response against tumor cells.
Minimizing the Risk of Cytokine Release Syndrome (CRS)	NK cell CAR therapy is not likely to induce severe cytokine release syndrome (CRS). Cytokine Release Syndrome (CRS) is a common occurrence in most CAR-T cell therapies. It is characterized by a systemic inflammatory response resulting from the rapid release of a significant quantity of cytokines into the bloodstream.
Multifunctional Effects	Natural killer (NK) cells not only directly kill tumor cells but also enhance the function of other components of the immune system by secreting a variety of cytokines. This includes the activation of T cells and macrophages.

NK Cell Separation and Expansion

BioVenic offers efficient and pure NK cell extraction and in vitro expansion technology derived from various animal sources. We employ advanced cell culture and expansion equipment to enhance expansion efficiency. By incorporating specific cytokines, we ensure the maximum quantity and efficacy of isolated and cultured NK cells, thereby meeting diverse research requirements.

NK Cell Phenotyping and Identification

BioVenic offers cell phenotyping identification and analysis solutions for projects focused on developing veterinary NK cell therapy. We utilize high-throughput detection technologies, such as flow cytometry, to analyze specific surface and internal markers of NK cells, ensuring both cell purity and functionality. Additionally, we provide detailed analysis based on comparative and bioinformatics analyses to guarantee that the identification results are accurate and thorough.

NK Cell Transformation

BioVenic draws upon extensive project experience in animal cell biology and comprehensive research on immune cells to meet customers' needs for targeted transformation aimed at enhancing the effectiveness of NK cells in veterinary cell therapy. Our advanced gene editing services, supported by a skilled technical team, offer personalized gene modification services utilizing CRISPR-Cas9 and other gene editing technologies to optimize NK cells for improved targeting and anti-tumor activity.

NK Cell Functional Testing

BioVenic offers a comprehensive array of functional tests for candidate NK cells used in veterinary cell therapy, including cytotoxicity assessments and killing ability evaluations. Our expert team enhances and validates the functionality of NK cells through both in vitro and in vivo models, delivers thorough evaluation results, and guarantees that the experimental data is both scientific and reliable.

Why Choose Us?

Efficient and Reliable Partner

We have developed advanced technology for the culture and expansion of animal immune cells, ensuring the efficient separation, extraction, and expansion of NK cells.

Expert Scientific Research Team

We have a highly experienced scientific research team specializing in immune cell therapy and animal cell biology, offering professional technical support and consultation throughout the entire process.

One-Stop Service

From cell extraction and phenotypic analysis to functional testing and gene editing, we offer a comprehensive range of NK cell therapy development services to effectively address your research needs.

Customized Solutions

BioVenic customizes personalized service content solutions and technical processes for each project, tailored to the specific needs of our customers.

As NK cell therapy demonstrates significant potential in the field of veterinary medicine, BioVenic remains dedicated to advancing this area by supporting therapy development projects in the scientific research phase. Leveraging a robust and comprehensive animal cell research platform, we offer a wide array of customized solutions for the research of veterinary NK cell therapy. If you have any related research needs or inquiries, please do not hesitate to contact us for further discussion.

References

Image retrieved from Figure 1 " Adoptive natural killer (NK) cell therapy." Kisseberth et al., 2021, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "Generation of ex vivo Expanded Canine NK Cells for Adoptive Immunotherapy."
Kisseberth, William C., and Dean A. Lee. "Adoptive natural killer cell immunotherapy for canine osteosarcoma." Frontiers in Veterinary Science 8 (2021): 672361.