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Animal Cell Line Development
Animal cell line development is a key process following animal cell isolation, in vitro growth, cell characterization, and passage technology. Basic animal cell line development aims to address the limitation of animal primary cells, which cannot be continuously expanded and utilized for in vitro research. As CRISPR technology and veterinary drug research advance, cell line technology is entering new frontiers. This includes the development of stable cell lines post-transformation and the creation of cell lines for recombinant protein expression production. Because animal living cells are complex, these complexities can be used to improve the yield and quality of animal-related biological products, thereby enhancing cost-effectiveness. Consequently, creating cost-competitive animal cell lines has become more appealing. BioVenic offers a range of scientific research services focused on animal cell line development. Our dedicated team provides services such as designing vectors, developing cell lines in vitro, and screening cell lines. We utilize genetic tools and expertise in animal cell reproduction and expression systems to expedite cell line development and produce high-performance, stable target cell lines for various applications.
Fig.1 Schematic Diagram of Developing the Mammalian Recombinant Protein Production Cell Line.1,2
Animal Cell Line Development Solutions
BioVenic offers a range of animal cell line products and provides customized solutions for animal cell lines with specific transformation requirements. We have developed a comprehensive animal cell gene editing platform, a high-throughput screening platform, and a platform for cell line characterization and amplification. By integrating cell transfection technology, we can efficiently create and produce target cell line products.
- Tumor Cell Lines
- Immortalized Cell Lines
- Reporter Cell Lines
- Knockout Cell Lines
- Knock-in Cell Lines
- Overexpression Cell Lines
Stable Cell Line Development
BioVenic has developed a series of stable animal cell line construction services for research purposes, leveraging its extensive expertise in animal cell-related products and services. We boast a comprehensive molecular biology and cell biology technology platform, along with a team of experts with rich experience in handling various animal cell lines. Proficient in utilizing cutting-edge technologies related to animal genome editing, BioVenic offers one-stop solutions for gene knockout, knock-in, knockdown, and reporter gene overexpression for your engineered target cell lines. Stable cell line products serve as essential scientific tools for veterinary drug screening and development, as well as gene and cell therapy research.
Fig.2 Flow Chart of Animal Stable Cell Line Development.
Immortalized Cell Line Development
BioVenic provides immortalization services for animal cell lines. Immortalized cell lines are derived from primary cells, bypass the normal cell aging process, and have an extended lifespan. We have a comprehensive platform and a professional technical team specializing in animal cell immortalization. The immortalized animal cell lines we construct maintain the biological characteristics of cells in vivo over multiple generations, with gene expression remaining stable. This helps reduce the variability in experimental results and minimizes differences between batches of cell lines. Immortalized cells are a very useful tool. They retain many characteristics of the primary cells, providing customers with an unlimited source of homogeneous cells for their research.
Fig.3 Schematic Diagram of Immortalized Cell Development.
Why Choose Us?
Cell Line Monoclonality
BioVenic ensures that the developed animal cell lines are derived from a single progenitor cell, ensuring the quality of the cell line. We utilize cutting-edge systems to verify monoclonality and detect cell growth processes.
Solution Flexibility
BioVenic adheres to the service tenet of providing targeted solutions to customers' personalized scientific research needs and customizes exclusive animal cell line development solutions for each researcher.
Service Professionalism
BioVenic is dedicated to users who require powerful and innovative animal cell line development. We collaborate with various molecular biology platforms to leverage expertise and enhance overall efficiency.
BioVenic can design and implement customized service solutions for cell line development with its many years of experience and professional background in animal cell and cell line products and services. Our specialized technical team solves problems for customers from the source. The entire service includes cell isolation, culture, characterization, amplification, and transformation until the establishment of the target cell line, addressing multiple related scientific issues in one comprehensive service. If you require customized animal cell line products for your project, please do not hesitate to contact us to discuss your requirements with our experts.
References
- Image retrieved from Figure 1 "Illustration of a typical process to develop a mammalian cell line for recombinant protein manufacturing." Lai et al., 2013, used under [CC BY 3.0] (https://creativecommons.org/licenses/by/3.0/). The original title was changed to "Schematic Diagram of Developing the Mammalian Recombinant Protein Production Cell Line."
- Lai, Tingfeng, Yuansheng Yang, and Say Kong Ng. "Advances in mammalian cell line development technologies for recombinant protein production." Pharmaceuticals 6.5 (2013): 579-603.