Animal Cell Line Identification

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Animal Cell Line Identification

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Animal Cell Line Identification Technology Species Identification Cell Characteristic Identification Why Choose Us?

Animal cell line authentication is essential for identifying and verifying model cells used in scientific research and veterinary drug development. Using cross-contaminated or misidentified cells in research can result in significant issues, including inaccurate research findings, unreliable data, irreproducible results, and potentially disastrous outcomes for clinical cell therapy. BioVenic offers researchers cell line authentication services to prevent issues during their projects. Precisely identifying and verifying target cell lines, as well as monitoring cross-contamination between them, not only saves researchers time and energy but also prevents irreversible catastrophic consequences. This process ensures the scientific integrity and reproducibility of experimental results. Our team of experts utilizes multiplex PCR detection, deep sequencing, DNA barcoding, RNA-seq, and other advanced identification technologies to create customized identity certificates and detailed reports for users' animal cell lines.

Fig.1 Mammalian Cell Line Identification and Contamination Assessment Model Flowchart.^1,2

Animal Cell Line Identification Technology

BioVenic has established a specialized comprehensive technology for identifying cell lines from different animal sources. Our technology meets the requirements for deep sequencing analysis, RNA-seq, chromosome analysis, isozyme analysis, and cutting-edge DNA barcode development for characterizing cell lines. It offers a one-stop solution for scientific challenges in verifying the identity of animal cell lines. Our cell line identification platform utilizes several authoritative animal cell databases for comparison, ensuring a reliable method to confirm the accuracy of cell lines and detect potential cross-contamination.

When is it necessary to identify animal cell lines?	How can cross-contamination of cell lines be reduced?
Before publishing an article or applying for project funding. Before utilizing cells for the advancement of veterinary cell therapy. When preparing to cryopreserve cells for many years. When it comes to the beginning or conclusion of a cell experiment. When conducting experiments on newly obtained cells or cells cultured for more than 5 generations. When the cell line is unstable, or the results significantly differ from expectations.	Obtain cell lines from reputable organizations or institutions. Conduct cell experiments by well-trained technicians. Package and use each cell line separately with corresponding culture media, solutions, or reagents. Routinely pay attention to the identity of the cell line and check for any signs of contamination. Make adequate preparation for cryopreservation. The number of cell culture generations should not be excessively high.

When is it necessary to identify animal cell lines?

How can cross-contamination of cell lines be reduced?

Before publishing an article or applying for project funding.
Before utilizing cells for the advancement of veterinary cell therapy.
When preparing to cryopreserve cells for many years.
When it comes to the beginning or conclusion of a cell experiment.
When conducting experiments on newly obtained cells or cells cultured for more than 5 generations.
When the cell line is unstable, or the results significantly differ from expectations.

Obtain cell lines from reputable organizations or institutions.
Conduct cell experiments by well-trained technicians.
Package and use each cell line separately with corresponding culture media, solutions, or reagents.
Routinely pay attention to the identity of the cell line and check for any signs of contamination.
Make adequate preparation for cryopreservation.
The number of cell culture generations should not be excessively high.

Animal Cell Line Identification Solutions

BioVenic conducts in-depth research on the technical process of animal cell line characterization and provides researchers with comprehensive and diverse animal cell line identification services. Our identification of normal cell lines primarily focuses on determining the cell's germline and tissue origin, assessing whether cells have undergone transformation and malignant changes, and checking for any cross-contamination. For tumor cell lines, our identification services focus on their malignancy. We conduct detailed characterization and identification of chromosomal abnormalities, changes in contact inhibition and density-dependent growth characteristics, colony formation ability, invasive growth in animals, and specific genetic and molecular level characteristics.

Species Identification

BioVenic has developed a comprehensive technology process for characterizing and identifying various animal cell lines. We can customize comprehensive solutions for cell species identification for our customers. Our laboratory is proficient in chromosome analysis, isozyme analysis, DNA barcode sequencing, and PCR methods. These techniques enable accurate analysis and identification of whether the target cell line originates from a single species of source cell and determine the source cell species. This proficiency reduces the risk of misidentification and cross-contamination of cells in research.

Cell Characteristic Identification

BioVenic is proficient in the standardized technical process of identifying relevant cell characteristics and uses analytical methods such as immunofluorescence or flow cytometry to perform cell characteristics and functional identification on animal cell lines from various sources. Our technicians characterize target cells using morphological methods, detect tissue-specific antigens, verify specific functions, and deeply analyze their identity information. We provide highly sensitive solutions for identifying specific animal cell lines. With many years of experience in animal cell characterization and identification, and a mature and integrated cell characteristic analysis platform, we provide detailed identification reports to customers.

Why Choose Us?

Customized Integrated Identification Solutions

BioVenic customizes the process of identification technology and development of evaluation models for the animal cell lines to be tested based on the individual project requirements of the client. This approach addresses the cell line identification needs of the entire project in a single solution.

Complete Coverage of Animal Cell Line Identification Methods

As an expert in the animal cell industry, BioVenic excels in the characterization and identification of cells from various species and tissues. We also support the development and implementation of solutions using advanced technologies such as deep sequencing, DNA fingerprinting, RNA-seq, and tissue-specific surface markers.

Comprehensive Cell Line Identification Report

BioVenic provides customers with detailed identification data and identity verification reports based on data comparison and database analysis. This includes virus and mycoplasma levels, genetic elements, phylogeny, allele information, and more.

BioVenic offers a complete range of targeted solutions for researchers dealing with cell line contamination issues. We provide a thorough analysis of the cell lines to be tested, focusing on species identification and cell function and characterization. With a full range of test equipment and professional experimental platforms, we support the characterization of animal cell lines from different sources at multiple levels, including genetics, morphology and functionality. This ensures the seamless progress of our customers' scientific research projects and helps to mitigate the risks associated with cross-contamination and misidentification of cell lines. If you have research needs related to animal cell and cell line identification, please feel free to contact us to discuss your research requirements.

References

Image retrieved from Figure 1 "Schematic overview of CeL-ID method." Mohammad et al., 2019, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "Mammalian Cell Line Identification and Contamination Assessment Model Flowchart."
Mohammad, Tabrez A., et al. "CeL-ID: cell line identification using RNA-seq data." BMC genomics 20 (2019): 17-29.