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Mouse Anti-Canine AKR1A1 Monoclonal Antibody
Product Overview
BioVenic mouse monoclonal antibody is specific for canine AKR1A1. It can be applied to WB, IHC and FACS assays of canine AKR1A1.
Specifications
Target Information
Canine aldo-keto reductase family 1 member A1 (AKR1A1) is a cytosolic enzyme that plays a significant role in detoxifying reactive aldehydes and maintaining cellular redox balance. It catalyzes the NADPH-dependent reduction of aldehyde groups to their corresponding alcohols, contributing to the metabolism of various endogenous and exogenous compounds. AKR1A1 has been shown to protect against oxidative stress by metabolizing lipid peroxidation products, such as 4-hydroxynonenal (4-HNE), which can cause cellular damage. In dogs, AKR1A1's activity is crucial for liver protection during chronic alcohol consumption, as it reduces the accumulation of harmful aldehydes and inhibits p53 activation, thereby preventing hepatocyte apoptosis and inflammation.
Shipping and Storage
This product is shipped with wet ice packs. Store at -20°C on receipt (up to 12 months). Avoid repeated freezing and thawing as this may denature the antibody.
Documents
The product is for research use only.
Not for commercial, prophylactic, diagnostic, or therapeutic applications.