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Veterinary Organoid Culture System Development
Organoids are in vitro tissue structures that mimic in vivo organs and can faithfully reproduce many characteristics of specific animal organs. Significant progress has been made in establishing 3D culture systems for animal stem cell-derived organoids. As a product of emerging technologies, 3D organoid structures combine the advantages of traditional 2D in vitro models and in vivo animal models, offering unprecedented opportunities to study the complexity of veterinary diseases, from pathogenesis to prevention, treatment, and potential organ replacement strategies. BioVenic focuses on developing veterinary organoid culture solutions for researchers and addressing technical challenges in the culture process. Organoids can be constructed from embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs), adult stem cells, or tumor cells in a specific 3D culture system. Our high-quality organoid culture technology processes provide a solid foundation and guarantee for the overall veterinary organoid solution.
Fig.1 Obtaining and Culturing Veterinary Organoids.1,2
Table 1 Comparison of Veterinary Drug Screening Models
| Organoid | Cell Line | Animal Model | |
| Dimension | 3D | 2D | 3D |
| Genetic Stability | High | Low | High |
| Gene Editing | Easy | Easy | Difficult |
| Physiological | Semi-physiological | Localized | Physiological |
| Heterogeneous | High | Low | High |
| Clinical Relevance | High | Low | High |
| High-throughput Screening | Achievable | Achievable | Difficult to achieve |
| Success Rate | High | High | Low |
Animal Tissue or Cell Collection
BioVenic provides solutions for acquiring and collecting living tissue cells for the veterinary organoid culture process. We have developed a comprehensive standard technical process and a customized service platform for isolating and obtaining suitable tissues or cells from animals, including somatic cells and stem cells. This ensures that the status and vitality of the primary cells and stem cells are maintained during the collection process.
Animal Stem Cell Culture
BioVenic has established a dedicated project team for the development of animal stem cell culture systems and media. BioVenic strictly standardizes the quality and efficiency of control service solutions. By combining stem cell culture technology with the adaptability of veterinary organoids, we tailor the culture conditions to the different types of target organoids. This enables the cells to effectively proliferate and grow.
Organoid Construction and Culture
BioVenic has developed a 3D cell culture technology platform for constructing and cultivating veterinary organoids. Our team of experts utilizes scaffold-based 3D cell culture or scaffold-free 3D cell culture methods to modify the culture medium composition and necessary elements like cytokines to support organoid growth. We culture the isolated animal cells to complete the in vitro generation and construction of organoids. After a cultivation period, we offer services to customers for further expansion of organoids or to maintain their physiological state.
Organoid Identification and Testing
BioVenic is equipped with a professional quality control and identification platform for organoid culture technology. We also offer customers testing and characterization services for veterinary organoids. Our comprehensive testing and identification process include morphological analysis, biomarker detection and genetic analysis to ensure that the organoids match the target organs in the animal body.
Flow Chart of Veterinary Organoid Culture
Why Choose Us?
BioVenic has reached a certain level of maturity in technologies related to 3D animal cell culture and organoid development. Our tailor-made service helps researchers to solve difficulties encountered in their veterinary organoid development projects.
BioVenic has a strong biological background and has been extensively involved in project research and development in the fields of animal cell biology, in vitro cell culture, preclinical development of cell therapy and veterinary drugs for many years.
BioVenic has established standardized technical processes for the cultivation of veterinary organoids to ensure that customers have access to high quality and reproducible solutions for the development of organoid culture systems.
BioVenic has initiated a range of tailored service projects for advanced veterinary organoids, encompassing solutions for the development of organoid culture systems. We are dedicated to providing comprehensive veterinary organoid culture system design and development for scientific research clients involved in the early stages of animal cell therapy and veterinary drug development. We aim to ensure the delivery of services of high quality, quantity and reliability through standardized processes and rigorous quality control systems. For further information, please do not hesitate to contact us.
References
- Image retrieved from Figure 2 "Current organoid culture techniques." Kar et al., 2021, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). The original title was changed to "Obtaining and Culturing Veterinary Organoids."
- Kar, Soumya K., et al. "Organoids: a promising new in vitro platform in livestock and veterinary research." Veterinary Research 52 (2021): 1-17.