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Veterinary Organoid-on-Chip System Development
Organ chip technology is a cutting-edge field of research that has emerged in recent years. This technology combines cell-cell interactions, matrix characteristics, and biochemical and biomechanical properties to construct a three-dimensional physiological microsystem of an animal organ on a chip. Organoid chips do not require complete reconstruction to mimic the entire organ; instead, they possess the physiological activity and structural and functional properties of the original organ tissue in the animal body. They are increasingly seen as a reliable alternative for predicting animal responses to drugs and various external stimuli. The challenge in developing veterinary organoid chips lies in the complex and unknown interactions between the environment and cells, as well as between cells, and in engineering the regulation and intervention of organoid self-organization. With a strong background in animal cell biology and expertise in cutting-edge microfluidic technology, BioVenic is dedicated to providing customers with comprehensive microfluidic solutions, including microfluidic chip customization, surface modification, microfluidic chip processing equipment and microfluidic instrumentation. In addition, we aim to integrate microfluidic solutions with organoid-related technology to establish customized services for the design and development of veterinary organoid chip systems.
Fig. 1 The application of organoids-on-a-chip platform in pancreatic islet research.1,2
Background of Veterinary Organoid Chips
In research related to the development of animal therapies, the advent of organoids has broadened the field. Organoids are miniature "organs" induced and cultured in vitro by stem cells that can partially reproduce the physiological functions of organs. Organ chips are miniature structures formed by the combination of microfluidic devices and living cells that can reproduce the physiological and pathological characteristics of organs in vivo in vitro. Organoid chips combine the advantages of both approaches. In the development of precision therapies for animal tumors, organoid models offer cost effectiveness and high efficiency. In veterinary drug discovery and development, organoids can serve as efficient models for high-throughput screening in animal tumors and rare diseases. Currently, the use of organoids in the development of cell therapy and veterinary drugs for companion animals is beginning to attract the attention of scientists, while organoid chips are still in the early stages of development.
Veterinary Organoid-on-Chip System Development Services
BioVenic collaborates with researchers to tackle various challenges in the development of veterinary organoid chip systems. We are committed to providing scientific and effective support through our expertise and research resources. Our microfluidic chip R&D team addresses scientific research issues for clients throughout crucial stages of organoid chip preparation, including cell inoculation, functional 3D structure formation, chip design, and sensor integration.
Microfluidic Chip Design and Development
BioVenic combines fundamental theory and project experience in cell biology, organoids and microfluidic chip development. We are dedicated to developing chips that mimic the physiological conditions and microenvironment of animal organs in vivo and accurately reproduce them in vitro.
3D Structure and Sensor Integration
BioVenic specializes in in vitro 3D culture of animal cells and integrates this with organoid chip development technology. Our expert team replicates the 3D structure of the target organ by utilizing various cell layers or appropriate matrices to mimic the organ's extracellular matrix. Our team is incorporating sensors into the development of veterinary organoid chips to enable real-time monitoring of key parameters such as oxygen levels, pH and temperature, making it easier to assess the health and functionality of the organoid.
Applications of Veterinary Organoid-on-Chip System
| Developmental Biology | Organoid chip system supports the construction of an in vitro animal developmental research model that accurately simulates the tissue structure of the target organ and the interaction between multiple organs. |
| Disease Model Construction | Culturing tumor cells or induced pluripotent stem cells from diseased animals on organoid chips has great potential in constructing specific disease models, thereby enabling the development of personalized therapy. |
| Veterinary Drug Development | Organoid chips offer the advantages of high throughput, seamless integration and reproducibility. They simulate the structure and physiological processes of different organs in a bionic microenvironment, replicating the interactions and crosstalk between organs and facilitating more complex and physiologically relevant research in veterinary drug development. |
Advantages of Veterinary Organoid-on-Chip Technology
- By integrating microfluidics technology, more accurate and controllable organoid model construction can be achieved. This technology can help control and simulate the microenvironment, vascularization, and interaction between tissues, thereby assisting in high-throughput analysis of organoid models.
- Organoid chips combine the advantages of medical biology and engineering. They can not only realize 3D cell culture and reproduce the relationships between cells and between cells and the matrix, but also simulate important in vivo microenvironments such as interstitial fluid and mechanical force stimulation of target organs in the body.
- Through real-time imaging, sensors, and other technologies, organoid chips offer unparalleled advantages in studying individual animal genetic development, disease occurrence and development mechanisms, veterinary drug screening, and immune evaluation in bionic microenvironments.
- Organoid chips are small in size and have multiple culture chambers, making them suitable for simultaneous multi-group control experiments. This greatly reduces individual differences and experimental cycles, enabling the study of single organoids and providing a strong argument for preclinical research.
Why Choose Us?
Cross-field Joint Development
Veterinary organoid chips combine the engineering advantages of organoids and microfluidic chips. Our scientific research provides reliable knowledge in both areas.
Systematic Solution Design
Our systematic solution combines chip materials, surface design, mechanical dynamics, sensors and high-throughput detection to provide customized solutions for the development of veterinary organoid chips that can have multiple applications.
Strict Quality Control System
We are equipped with standardized quality control procedures in animal stem cell culture, differentiation and in vitro organoid research technology to ensure the steps in veterinary organoid-on-a-chip development.
BioVenic has established a highly professional scientific research team specializing in cytology and biomedical engineering. The team possesses a strong innovative spirit and expertise in animal cell therapy and veterinary drug development. We integrate cutting-edge technologies and top-tier talents from various high-precision biological sectors, including organoid engineering, 3D cell culture, microfluidic chip development and preparation, and high-throughput detection platforms. Our commitment is to consistently deliver high-quality solutions to our customers. If you are interested in BioVenic's veterinary organ-on-a-chip research solutions, please contact us with your research interests and we will be happy to discuss further with you.
References
- Image retrieved from Figure 1 "The application of organoids-on-a-chip platform in pancreatic islet research." Yin et al., 2022, used under [CC BY 4.0] (https://creativecommons.org/licenses/by/4.0/). Without modification.
- Yin, Jiaxiang, et al. "Pancreatic islet organoids-on-a-chip: how far have we gone?" Journal of Nanobiotechnology 20.1 (2022): 308.