Animal Embryonic Stem Cell Engineering

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Animal Embryonic Stem Cell Engineering

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ESC Stemness Regulation Engineering ESC Genetic Engineering Applications of ESCs in Animal Production and Welfare Why Choose Us?

Animal embryonic stem cells (ESCs) are derived from the inner cell mass of early embryos and can be cultured indefinitely in vitro. They have the ability to self-renew and differentiate into all adult cell types. Because of their unique functions, ESCs are used in the development of animal disease models and in regenerative medicine research. For many years, BioVenic has been dedicated to the in-depth analysis of the molecular mechanisms of self-renewal and pluripotency regulation of animal stem cells. We provide researchers with customized engineering solutions for stem cell applications. We combine cell biology with multi-omics platforms to collect ESC omics data and systematically identify genes or regulatory pathways associated with their self-renewal and pluripotency. At the same time, we offer genome editing services in ESC engineering, providing customers with animal ESC cells and experimental solutions for gene recombination modification and gene function research.

Animal ESC Engineering Solutions

BioVenic integrates multi-omics data from animal ESCs, including information on transcriptome, histone modification, chromatin accessibility and transcription factors. This integration allows a comprehensive exploration of gene targets and regulatory mechanisms that influence stem cell self-renewal and pluripotency. We offer customized solutions for engineering projects related to the exploration of ESC pluripotency mechanisms and genome modification.

ESC Stemness Regulation Engineering

BioVenic has conducted in-depth research on the regulation and maintenance of animal ESCs, focusing on analyzing the principles of maintaining pluripotency and differentiation potential of cells from the level of gene expression regulation. Our R&D team provides reliable research support to researchers conducting research related to animal ESC stemness regulation. We achieve the regulation of animal ESC stemness through the expression regulation of stemness genes and differentiation genes, and the improvement of ESC microenvironment. We accurately capture cell differentiation nodes and ensure the vitality of cells cultured in vitro.

ESC Genetic Engineering

BioVenic has a mature Cas9 system suitable for animal cells, which enables customers to perform gene targeting using animal ESCs. This system offers significant advantages, including high throughput targeting in vitro, multi-allele manipulation, and efficient editing. In addition, our solution supports large-fragment knockout in ESCs, enriching a more comprehensive gene editing research model. Our ESC gene editing solution provides a more efficient, convenient and reliable scientific research tool for studying genetic modifications in livestock and companion animals.

Fig.1 Animal ESC Genetic Engineering. (BioVenic Original) Fig. 1 Flow Chart of Animal ESC Genetic Engineering.

Applications of ESCs in Animal Production and Welfare

Cell Therapy	ESCs have great potential for differentiation and proliferation, high regenerative capacity, and broad prospects for the treatment of animal diseases. Establishing a stable ES cell line from livestock or companion animals is the first step in advancing stem cell therapy.
Animal Models	ESCs from farm animals such as pigs, cattle, sheep, goats or horses are used to develop and validate animal models for the evaluation of stem cell therapies. The creation of animal disease models through embryonic stem cell engineering serves to increase the economic importance, utility and application of animals in veterinary medicine.
Animal Breeding	Cultivating a population with superior traits using ESCs is incomparable to traditional animal breeding methods in terms of time, manpower, and material resources.

Why Choose Us?

BioVenic has extensive hands-on experience and a strong professional background in animal stem cell projects, particularly embryonic stem cells (ESCs), ensuring scientific rigor and feasibility of solutions.

BioVenic has developed customized standardized operating procedures and maintenance measures for animal ESCs that are difficult to culture in vitro. These protocols aim to reduce cell loss and maintain cell viability during the implementation process.

BioVenic's technology includes animal ESC isolation and culture, animal genome precision editing, and stem cell-directed differentiation to ensure seamless implementation of customized services at all levels of ESC engineering.

BioVenic has extensive project experience in the field of animal stem cells, utilizing advanced cytology and molecular biology technology platforms to provide reliable solutions for comprehensive animal embryonic stem cell research projects. We are dedicated to advancing fundamental technologies for researchers to investigate the principles of ESC stemness regulation, establish standardized gene modification procedures, and explore applications in cell therapy and veterinary therapy development. If you are looking for a research partner for animal ESC studies, please contact us to discuss your customized experimental plan.