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Animal Embryonic Stem Cell Directed Differentiation
With the development and advancement of animal stem cells and veterinary regenerative medicine and cell therapy research, significant progress has also been made in the field of inducing stem cell differentiation from a variety of sources. Embryonic stem cell induced differentiation is a key point in stem cell research, which can induce osteoblasts, chondrocytes, adipocytes, neurons, cardiomyocytes, endothelial cells and other progeny cells. BioVenic has mastered a variety of technologies to induce directional differentiation of ESCs and can easily achieve cell induction differentiation for customers, including exogenous molecule induction, transgenic induction and cell co-culture to induce stem cell differentiation. With our powerful genome editing platform, we support ESCs for in vitro genetic modification, which helps to reveal the regulation and function of specific genes during differentiation and development.
Fig.1 In vitro differentiation protocols yield a variety of unique cell-types.1,2
BioVenic has mastered a variety of technologies to achieve the differentiation of animal embryonic stem cells into different lineage cell types and offers personalized, tailor-made services to researchers worldwide. We categories solutions based on induction differentiation technology, enabling customers to understand and select the service direction that matches their project content.
Transgenic-induced Directed Differentiation
BioVenic uses transgenic methods to provide animal ESC directed differentiation solutions, combining state-of-the-art transgenic, gene modification and gene transfection technologies to ensure efficient and reliable services. Our technicians mainly use gene transfection technology to overexpress differentiation-promoting genes in ESCs, thereby regulating the differentiation of ESCs. At the same time, by transferring target genes of key signal transduction components into ESCs, we effectively induce ESCs to differentiate specifically in the direction of customers' needs.
Cell Co-culture-induced Directed Differentiation
BioVenic recognizes that the microenvironment has a significant impact on the differentiation of ESCs. Therefore, we have developed engineering services for directed induction to meet the specific project needs of our customers. Our research team is dedicated to conducting in-depth research and development of induction strategies that integrate cell co-culture. We are committed to creating reliable induction protocols for our customers.
Small Molecule-Induced Directed Differentiation
BioVenic provides cytokines and growth factors to induce differentiation of animal ESCs and control cell fate. Our team of experts integrates cutting-edge technologies and in-depth research in the fields of developmental biology and stem cells. We are committed to using small molecules to influence gene-level regulation and signaling in ESCs, to inhibit self-renewal signaling pathways and to promote the differentiation of cells into specific lineages.
Table 1 Small Molecules Commonly Used in Directed Differentiation of Mammalian ESCs.
| Lineages | Differentiation | |
| Embryonic Germ Layers | Endoderm |
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| Mesoderm |
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| Ectoderm |
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| Germ cells |
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| Trophectoderm |
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| Extraembryonic Endoderm |
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Why Choose Us?
Animal Stem Cell Expert
BioVenic has long been involved in animal stem cell research and has many years of project experience in this field. The company is professional and reliable in inducing ESCs to differentiate into specific germ layer cells.
Diversified Differentiation Technology
BioVenic has expertise in technical methods to determine and control the fate of animal ESCs using cytokines, small molecules, co-culture and transgenics.
Frontier Stem Cell Technology Platform
BioVenic combines stem cell isolation, culture, animal genome editing and directed differentiation technology platforms for stem cells to ensure seamless implementation of service solutions in all aspects.
BioVenic provides comprehensive solutions to the challenges of scientific research projects involving animal embryonic stem cells. We develop and design customized one-stop solutions to effectively address these issues. Animal ESCs play a critical role in the in vitro research phase of veterinary and cell therapy development. The technology to induce their directed differentiation into specific lineage cells is particularly important. We are proficient in both traditional small molecule induction methods as well as cutting-edge cell co-culture and transgenic induction techniques to fully meet the unique requirements of our clients' projects. If you are facing challenges in manipulating the fate of ESCs, please contact us to explore exclusive solutions together.
References
- Image retrieved from Figure 1 "Stem cell therapy viewed from the standpoint of developmental biology." Rasmussen, 2003. The original title was changed to "In vitro differentiation protocols yield a variety of unique cell-types."
- Rasmussen, Theodore P. "Embryonic stem cell differentiation: a chromatin perspective." Reproductive biology and endocrinology : RB&E vol. 1 100. 13 Nov. 2003, doi:10.1186/1477-7827-1-100. This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original URL.