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Chemical Synthesis of Conjugate Veterinary Vaccine
As one of the most abundant, diverse, and complex natural polymers, polysaccharides located on the surface of pathogens can be used as vaccine antigens to stimulate the body to produce an immune response. Meanwhile, since most polysaccharides are unable to induce T cell-mediated immune responses, polysaccharides will be attached to carriers in order to enhance the immunogenicity of polysaccharide antigens. Chemical synthesis of polysaccharide-carrier proteins is currently a more mature method of preparation, and BioVenic provides a chemical synthesis platform to help you complete the development of conjugate veterinary vaccines in a comprehensive way, from polysaccharide extraction to carrier protein preparation.
Our Services
Conjugate veterinary vaccines are prepared using a chemical method in which polysaccharides and carrier proteins are directly coupled together by chemical cross-linking. BioVenic provides a technology platform that covers comprehensive services in the veterinary vaccine development process.
Polysaccharide Extraction
The extraction and subsequent processing of polysaccharide antigens, the mainstay of conjugate veterinary vaccines, from pathogens is the first step in the development of conjugate veterinary vaccines. BioVenic provides these services to help you lay a solid foundation for your development.
Carrier Proteins
Carbohydrate antigens can be conjugated with a range of proteins, such as outer membrane proteins (OMPs), bacterial pili, and secreted toxins from pathogenic bacteria, to enhance their immunogenicity. Among the available carrier proteins, tetanus, and diphtheria toxoids are the most commonly employed due to their widespread availability and suitability for this purpose. Our carrier protein production and purification services include but are not limited to the following.
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Conjugation
Before coupling of polysaccharides and carrier proteins, they need to be activated separately to introduce reactive sites. BioVenic provides activation of polysaccharides and carrier proteins during the development of conjugate veterinary vaccines to enable them to react and form couplings efficiently. And BioVenic also provides quality control and validation services to confirm the final polysaccharide-carrier protein complex to ensure product consistency and stability, using means including mass spectrometry, SDS-PAGE electrophoresis, ELISA, etc.
Why Choose Us?
BioVenic utilizes flexible chemical synthesis of conjugate veterinary vaccines that is applied to a wide range of combinations of polysaccharides and carrier proteins and can therefore be used to develop different types of vaccines for different pathogens.
BioVenic offers many types of chemical cross-linking methods to meet your needs in different species of animal vaccine development.
BioVenic establishes appropriate quality control methods to ensure the stability, safety and lot-to-lot consistency of conjugate veterinary vaccines.
The strength of chemical synthesis method as a proven methodology allows BioVenic to provide first-class, efficient service throughout the entire process of conjugate veterinary vaccine development using this methodology with specialized knowledge and stringent quality control to ensure the excellence and immunogenicity of final products. Contact us today, accelerate your vaccine development efforts and address the evolving complexities of animal health.
Reference
- Zhou, Yang; et al. "Chemical synthesis of polysaccharide–protein and polysaccharide–peptide conjugates: A review." Carbohydrate Polymers 274 (2021): 118662.