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Feed Postbiotics-Extracellular Polysaccharides
Extracellular polysaccharides (EPS), also known as exopolysaccharides, exhibit structural and functional diversity reflecting the microorganisms from which they originate. They are found in various forms such as cell-bound capsular polysaccharides, unbound "slime", and as part of the O-antigen component of lipopolysaccharide, showcasing a broad array of biological functions. BioVenic offers tailored solutions for utilizing extracellular polysaccharides as postbiotics in animal feed. Our comprehensive suite of services includes analytical solutions for EPS, safety and efficacy assessments, mechanism studies, and production optimization.
Fig. 1 EPS material released from Bifidobacterium animalis subsp. lactis S89L1,2
Biological Functions of EPS
EPS derived from diverse sources are shaped by factors like monosaccharide composition, glycosidic linkage, and chemical modifications, which determine aspects such as conformation, chain expansion, and molecular weight. These constituents collectively contribute to the health-promoting attributes of EPS. Probiotic bacteria-produced EPS are particularly noteworthy for their therapeutic value, encompassing antimicrobial, immunomodulatory, anti-inflammatory, antioxidant, anti-tumor, anti-viral, anti-diabetic, anti-ulcer, and cholesterol-lowering activities.
Extracellular Polysaccharides Structural Analysis
The structural details of extracellular polysaccharides are elucidated through examination of monosaccharide composition, anomeric configurations, glycosidic linkages, the presence of repetitive units, noncarbohydrate substituents, and the depiction of a chemical molecular structure or a composite model. Various techniques such as hydrolysis for chemical degradation, SEC-chromatography and HPLC/HPAEC for separation, and NMR spectroscopy for identification aid in the analysis of microbial extracellular polysaccharides. This information is crucial for developing extracellular polysaccharides for application in animal feed postbiotics.
Safety and Efficacy Assessment of Extracellular Polysaccharides
Our platform for feed safety analysis is proficient in identifying detrimental components, such as toxins, within extracellular polysaccharides products that may pose risks to animals. Furthermore, we offer a diverse array of animal in vivo and in vitro models to assess the safety and efficacy of exopolysaccharides in specific animal contexts. Key research areas encompass evaluating the impact of extracellular polysaccharides on growth patterns, intestinal well-being, immune responses, and antioxidant capabilities.
Exploration of Mechanisms Involving Extracellular Polysaccharides
The varied landscape of polysaccharide structures, properties, and functions underscores the critical role of this matrix component in enabling bacteria to thrive across diverse environments. Through our specialized microbial extracellular polysaccharide research infrastructure, we delve into the structural attributes of microbial extracellular polysaccharides and their effects in both in vitro and in vivo settings. This facilitates a thorough investigation into the mechanisms underpinning the actions of microbial extracellular polysaccharides.
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Feed Extracellular Polysaccharide Postbiotics Development
The efficacy of extracellular polysaccharide production is intricately linked to the fermentation conditions and genetic makeup of microorganisms. Through optimizing fermentation parameters and employing genetic engineering methodologies, we help enhance the output of bacterial extracellular polysaccharides. Additionally, our solutions assess the safety and effectiveness of extracellular polysaccharide products, enabling a comprehensive study of their mechanisms of action. This aids researchers in uncovering the potential benefits of extracellular polysaccharides for various animal applications.
Applications of Extracellular Polysaccharides Postbiotics in Animals
Various types of microbial extracellular polysaccharides elicit distinct effects in animals based on breed, age, and developmental stages. Key impacts include enhancements in immune function, growth promotion, and pathogen resistance. Table 1 delineates specific application effects of select microbial extracellular polysaccharides in animals, showcasing their diverse and beneficial applications.
Table. 1 Effects of extracellular polysaccharides on animals
| Animal Types | Source of Extracellular Polysaccharides | Effects |
|---|---|---|
| Pigs | Ganoderma lucidum | Improved immune function and meat quality of finisher pigs. |
| Pigs | Yeast | Inhibited virus replicates, improved intestinal morphology, enhanced antioxidant capacity, relieved inflammation and regulated the metabolism of the intestine in PEDV-infected piglets. |
| Pigs | Lactobacillus reuteri | Protected against enterotoxigenic Escherichia coli in piglets. |
| Chickens | Ligilactobacillus salivarius | Simulated lactobacilli growth. May be an alternative to plant prebiotics such as inulin at poultry. |
| Chickens | Antrodia camphorata | Enhanced the immune functions of the organs in SPF chickens and could be an attractive application of nutraceuticals and pharmaceuticals. |
Why Choose Us?
We leverage cutting-edge analytical technology platforms for characterizing the structure of extracellular polysaccharides, forming the foundation for nuanced biological function research.
Our extensive array of in vivo and in vitro animal models allows us to explore the effects of extracellular polysaccharides on animals from diverse perspectives.
With researchers skilled in animal nutrition, we tailor solutions to develop postbiotic extracellular polysaccharides that align with your specific requirements.
Extracellular polysaccharides, recognized for their multifaceted biological activities, hold significant promise in animal feed applications. Through our advanced solutions for the development of postbiotic feed extracellular polysaccharides, BioVenic uses a range of sophisticated analytical techniques and various in vivo and in vitro animal models to analyze the postbiotic activity of extracellular polysaccharides from bacteria, fungi and other microorganisms, to reveal their effects and delve into their mechanisms of action to broaden their scope of application. Should our feed postbiotic extracellular polysaccharide solutions pique your interest, please contact us with your research needs, and we are committed to delivering viable and tailored solutions for your endeavors.
References
- Image retrieved from Figure 1 "EPS-producing Bifidobacterium animalis subsp. lactis S89L visualized with a cryo-scanning electron microscope (A dotted line 1 μm) and EPS material released from the bacterium (B solid line 5 μm)." Castro-Bravo et al., 2018, used under [CC BY 4.0]. The original image was modified by extracting and using only part B, and the title was changed to "EPS material released from Bifidobacterium animalis subsp. lactis S89L".
- Castro-Bravo, Nuria, et al. "Interactions of surface exopolysaccharides from Bifidobacterium and Lactobacillus within the intestinal environment." Frontiers in Microbiology 9 (2018): 416278.