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Feed Postbiotics-Vitamins
Vitamins are important metabolites of microorganisms and play an important role as postbiotics in animal nutrition. BioVenic's feed postbiotic vitamin solutions can assist animal nutrition researchers in a variety of ways. These include vitamin analysis, genetic screening of vitamin-producing strains, conducting safety and efficacy evaluations of microbial vitamins, optimizing microbial vitamin fermentation, and providing product development services. By utilizing our various advanced technologies, animal nutrition researchers can advance the application of microbial-derived vitamins as feed postbiotics.
Table. 1 Various vitamin and their producing microorganisms1
| Vitamins | Descriptions | Vitamin-Producing Microorganisms |
|---|---|---|
| Vitamin B1 | Thiamine pyrophosphate (TPP), the active form of thiamine, can inhibit cholinesterase activity, reduce skin inflammation, prevent seborrheic dermatitis or eczema, and enhance skin health. |
Escherichia coli Salmonella typhimurium Bacillus subtilis |
| Vitamin B2 | An essential precursor of flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). |
Ashbya gossypii B. subtilis |
| Vitamin B3 | Niacin serves as the precursor in the synthesis of pyridine coenzymes NAD (nicotinamide adenine dinucleotide) and NADP (nicotinamide adenine dinucleotide phosphate). | Recombinant E. coli expressing Rhodococcus rhodochrous nitrile hydratase |
| Vitamin B5 | Also known as pantothenic acid, composed of pantoic acid and β-alanine (β-Ala), a precursor of coenzyme A. | Genetic modified Corynebacterium glutamicum and B. subtilis |
| Vitamin B6 | A water-soluble vitamin existing in phosphate form in the body. | Sinorhizobium meliloti |
| Vitamin B7 | Essential for the normal metabolism of fats and proteins. |
C. glutamicum Mesorhizobium loti S. meliloti. |
| Vitamin B9 | Natural folic acid primarily found as polyglutamic acid, with the biologically active form being tetrahydrofolate. |
Bioengineered B. subtilis A. gossypii |
| Vitamin B12 | The largest and most complex vitamin molecule discovered to date. |
Pseudomonas denitrificans Propionibacterium freudenreichii Propionibacterium shermanii |
| Vitamin C | Functions as an antioxidant, scavenging free radicals and reducing oxidative stress. |
Gluconobacter oxydans Bacillus megaterium Ketogulonigenium vulgare |
| Vitamin A | Includes β-carotene, α-carotene, and β-cryptoxanthin. β-carotene, an antioxidant, inhibits singlet oxygen and lipid peroxidation, crucial for disease prevention. | Mainly produced by fungi and some bacteria |
| Vitamin D | Group of fat-soluble secosteroids enhancing intestinal absorption of magnesium, calcium, phosphate, with various biological effects. |
Rhodococcus Streptomyces Pseudonocardia sp. Mycobacterium |
| Vitamin K | A fat-soluble vitamin, also known as the blood coagulation vitamin, promoting blood coagulation and preventing osteoporosis. |
B. subtilis E. coli lactic acid bacteria Flavobacterium sp. B. amyloliquefaciens |
Feed Postbiotics Vitamins Analysis
We provide a diverse array of cutting-edge methods for analyzing vitamins in feed postbiotics. Our advanced techniques can identify both water-soluble and fat-soluble vitamins across various feed and animal samples. Through our assessments, animal nutrition researchers can precisely measure the vitamins generated by microorganisms, both in vivo and in vitro, aiding in the comprehension of vitamin production and metabolism. Our methods for determining vitamins encompass:
- Fluorimetry and colorimetry,
- Liquid-phase chromatography with ultraviolet or fluorimetric detection,
- Gas-phase chromatography,
- Microbiological assays.
Genetic Study of Vitamin-Producing Strains
- Genomic Exploration
Through comprehensive genomic sequencing and advanced bioinformatics analysis, we delve into the genomes of vitamin-producing microorganisms. This exploration aids in understanding the mechanisms behind vitamin synthesis in these strains, offering crucial insights for potential modifications to enhance vitamin output.
- Genetic Engineering of Vitamin-Producing Strains
Leveraging specific microbial genomic data, we engage in genetic manipulation to engineer strains capable of proficiently generating targeted vitamins. Our genetic modification toolkit empowers the enhancement of vitamin production efficiency while streamlining the challenges encountered during strain development.
Safety and Efficacy Evaluation of Microbial Vitamin
- Safety Evaluation
Our services encompass detailed assessments of vitamin-producing strains, delving into genetic profiles to identify the presence of virulence genes, antibiotic resistance markers, and more. Additionally, we conduct rigorous analyses to ensure the absence of chemical and microbial contaminants in vitamins derived from microbial fermentation.
- Efficacy Evaluation
Drawing on vitamin characteristics, our services extend to exploring in vitro antibacterial efficacy and antioxidant capabilities. Moreover, through in vivo trials on animal models, we evaluate growth performance, health metrics, product quality, and other parameters, enabling a comprehensive assessment of vitamin efficacy across various animal species.
For more information, please visit the following links.
Microbial Vitamin Fermentation Optimization
Our tailored fermentation solutions for optimizing microbial vitamin fermentation involve customizing media ratios based on the physiological traits of vitamin-producing strains. This approach boosts vitamin fermentation output, reduces production expenses, and expedites the industrial deployment of microbial vitamins.
Microbial Vitamin Postbiotics Development
We specialize in comprehensive microbial vitamin product development services, offering end-to-end solutions. From strain screening and fermentation process enhancement to microbial vitamin quality assurance, safety and efficacy studies, and the creation and assessment of varied vitamin product formats (liquid, solid, mixed), our services address critical aspects of microbial vitamin product development.
Feed Postbiotics Vitamins Development Workflow
Why Choose Us?
With our advanced testing and analysis platform, we can help researchers develop microbial strains for vitamin production and improve the availability of microbial resources.
Our staff has extensive research experience in animal nutrition, including vitamin nutrition, and can provide you with rational solutions.
Our solutions are designed to provide you with a comprehensive service by integrating a variety of advanced technologies from the perspective of your research as a whole.
Various vitamins produced by microorganisms are important for animal growth and health, as well as for the composition of intestinal microorganisms. BioVenic offers a one-stop solution for vitamin testing and analysis, strain development, safety and efficacy evaluation, and vitamin product development. If you are interested in our postbiotic vitamin solutions for animal feed, please contact us and we will be happy to understand your research needs and provide further solutions.
Reference
- Wang, Yanyan, et al. "Microbial cell factories for green production of vitamins." Frontiers in Bioengineering and Biotechnology 9 (2021): 661562. Under Open Access license CC BY 4.0. Some of the original article's content has been summarized in the table.