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Feed Postbiotics-Cell Lysates
The lysates derived from certain bacteria or fungi—rich in sugars, proteins, antimicrobial peptides, and other bioactive compounds—can positively influence animal growth performance, immunity levels, antioxidant status, and overall product quality. BioVenic offers comprehensive solutions for microbial lysate postbiotics, including detection and analysis of biologically active ingredients, evaluation of their effects in vivo and in vitro, mechanistic studies, and product development.
Feed Postbiotics Cell Lysates Analysis
Microbial cell lysates encompass a mix of biologically active compounds with diverse roles. Our feed analysis tools aid in assessing common dietary compositions like proteins, fats, and carbohydrates within these microbial cell lysates. Leveraging advanced techniques such as GC-MS, HPLC, and NMR, we pinpoint and evaluate the functional constituents. High-throughput metabolite analysis technologies assist in identifying specific metabolites and uncovering new ones. Moreover, our platform enables the customization of targeted assays for specific components within the microbial cell lysates.
In Vivo and In Vitro Evaluation of Cell Lysates
- Feed Postbiotics Cell Lysates Safety Evaluation
Given their microbial origins, it's crucial to verify the safety of cell lysates both in vivo and in vitro. We can assess the genetic safety of microorganisms and detect potential contaminants like endotoxins, mycotoxins, and heavy metals. Our animal models are capable of evaluating the safety of these microbial cell lysates by observing changes in appearance and biochemical indicators.
Table. 1 Safety concerns about microbial cell lysates
| Safety concerns | Description |
|---|---|
| Pathogenic Contamination | Verifying absence of disease-causing organisms in microbial cell lysates. |
| Endotoxins | Monitoring and controlling levels of Lipopolysaccharides (LPS) from gram-negative bacteria to prevent septic shock risks. |
| Allergenicity | Identifying allergenic factors in microbial lysates to avert allergic reactions in animals. |
| Toxins | Assessing for presence of harmful toxins or mycotoxins in microbial cell lysates to safeguard animal health. |
| Antibiotic Resistance | Mitigating risks of transmitting antibiotic resistance genes to animal gut microbiomes or the environment. |
| Heavy Metal Contamination | Evaluating levels of heavy metals in microbial cell lysates during cultivation and processing to ensure safety. |
| Dosage | Establishing optimal dosages for maximizing benefits while minimizing adverse effects. Long-term effects on animal health and product quality are also a focus of study. |
- Feed Postbiotics Cell Lysates Efficacy Evaluation
Microbial cell lysates can exhibit biological activities such as immunomodulation, antioxidant, and antibacterial effects. Using various in vitro and in vivo models, combined with technologies like metabolomics, microbiome analysis, and proteomics, we offer tailored solutions for evaluating these effects in contexts critical to animal nutrition research.
Mechanism Study of Feed Postbiotics Cell Lysates
Our mechanism study services integrate animal model research with microbial lysate analysis to provide comprehensive insights into single metabolites, genomes, microbiomes, proteomes, and metabolomes. This approach helps researchers understand how different cell lysates impact animal nutrition and health by correlating various indicators with genomic data.
Table. 2 Bioactive components in microbial cell lysates
| Bioactive Components | Examples |
|---|---|
| Polysaccharides | β-Glucan, mannan, trehalose |
| Bioactive Peptides | Antioxidant peptides, antimicrobial peptides |
| Nucleotides | Yeast nucleotides |
| Vitamins | Vitamin B12, vitamin B6 |
| Short Chain Fatty Acids | Acetate, propionate, butyrate, pentanoate, malonate |
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Feed Cell Lysate Postbiotics Development
Microbial cell lysates are generated through mechanical force, chemical treatments, or enzymatic digestion. Our innovations optimize the enzymatic production method, increasing its effectiveness for creating animal postbiotics. Each microbial strain undergoes individual production, harvesting, specific inactivation treatment, and optional lyophilization. The synthesis of a polyvalent microbial cell lysate involves blending distinct lysates in preset proportions.
Effects of Feed Postbiotics Cell Lysates on Animals
Microbial cell lysates contain various beneficial compounds like peptides, enzymes, vitamins, and other metabolites. These have the following potential effects on animals:
| Effects | Description |
|---|---|
| Gut Health Improvement | Enhances gut microbiome diversity, strengthens intestinal barriers, reduces inflammation, and promotes beneficial gut microbes. |
| Immune System Modulation | Stimulates immune responses, increases antimicrobial peptides and cytokines, improves pathogen resistance. |
| Growth Performance Enhancement | Boosts growth rates, improves feed conversion efficiency, enhances overall productivity, and positively influences nutrient utilization. |
| Pathogen Inhibition | Exhibits antimicrobial properties, reduces infection risks and antibiotic needs. |
| Stress Reduction | Lowers stress levels and enhances animal resilience, improving welfare and productivity. |
| Egg and Milk Quality Improvement | Enhances quality and nutritional profile of eggs and milk in laying hens and dairy animals. |
Why Choose Us?
We provide advanced omics technologies and data analysis services to study microbiota, metabolites, and proteins for applying microbial cell lysates across various animals.
Our in vivo and in vitro models cater to a broad range of animals, essential for thorough safety and efficacy evaluations of microbial cell lysate feed postbiotics.
Our assay platforms are adept at detecting numerous bioactive components in cell lysates, and we can develop specific assays to meet research needs.
With our comprehensive range of services, including feed analysis, safety and efficacy evaluations, mechanistic research, and product development solutions, BioVenic offers a one-stop solution for developing microbial cell lysates as feed postbiotics for animals. If you're interested in our cell lysate feed postbiotics solutions, please contact us to discuss your research program further.