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Feed Postbiotics-Microbial Cell Fragments
Microbial cell fragments refer to components or extracts derived from microbial cells like bacteria, yeast, and fungi, which find applications in animal nutrition. At BioVenic, we specialize in developing diverse types of microbial cell fragments as feed postbiotics. Our comprehensive solutions include feed analysis, assessing in vivo and in vitro application effects, conducting mechanism studies, and facilitating the production development of microbial cell fragments for postbiotics.
Main Types of Microbial Cell Fragments
Postbiotics retain various components and molecules derived from microorganisms even after processing, which contribute to host health in different ways. The key types of microbial cell fragments functioning as postbiotics in animals are described below:
Table. 1 Main types of microbial cell fragments
| Types | Descriptions |
|---|---|
| Peptidoglycan | This comprises β-1,4-linked N-acetylglucosamine and N-acetylmuramic disaccharide units, making up approximately 90% of the weight of the cell wall in gram-positive bacteria. |
| Teichoic acids | These are anionic polymers consisting of alditol-phosphate repeating units and are classified as wall teichoic acids (WTAs) and lipoteichoic acids (LTAs). Teichoic acids play important roles in host-cell adhesion, inflammation, and immune activation. The diversity of WTA structures and the immunological signaling of WTA are subjects of ongoing discussion, while safety testing is required due to the potential for excessive inflammatory response. |
| Bacterial wall polysaccharides | These can be categorized into exopolysaccharides (EPS), capsular polysaccharides (CPS), and cell wall polysaccharides (WPS). EPSs are loosely associated with the cell surface, CPSs are permanently attached, and WPS may or may not be covalently attached to the cell wall but do not form a capsule. |
| S-layer proteins (SLPs) | Gram-positive and gram-negative bacteria possess proteinaceous surface layers known as S-layers that provide important functional properties. S-layer proteins are abundant cellular proteins that interact with the host and its immune system. |
| Bacterial DNA | Vertebrate immune systems, especially unmethylated cytosine-guanine dinucleotide (CpG motifs) within bacterial DNA, can recognize these motifs under specific base contexts. |
Fig. 1 Beneficial compounds and mechanisms of postbiotics in animal gut health and production1
Microbial Cell Fragments Analysis
We possess a comprehensive analytical platform for feed and additives, enabling us to measure or quantify the content of functional components (e.g., peptidoglycan, teichoic acids), sugars, and protein fractions in microbial cell fragments. Additionally, our analytical products and services encompass toxins, lipopolysaccharides, and more, aiding in the safety testing of microbial cell fragments.
Safety and Efficacy Study of Microbial Cell Fragments
Since microbial cell fragments may exhibit varying effects across different animals due to distinct microbial structures and compositions, safety validation is crucial to determine their suitability as feed additives for specific animal species. Our wide range of in vitro and in vivo animal models facilitates safety and efficacy studies of microbial cellular fragments. Through our animal nutrition and metabolism analysis platform, we conduct individual and omics analysis, evaluating various animal biochemical, immunological, antioxidant, microbial metabolite, and microbiome parameters to support the development of microbial cell fragments as feed postbiotics.
Mechanism Study of Microbial Cell Fragments
The health benefits provided by postbiotics can arise from multiple mechanisms, including beneficial regulation of the microbiome, enhancement of epithelial barrier function, modulation of immune responses, regulation of systemic metabolism, and signaling through the nervous system. We offer solutions to investigate the functional mechanisms of different microbial cell fragments.
Feed Microbial Cell Fragment Postbiotics Development
The production of microbial cellular fragments involves complex physical, chemical, and biological steps. Our solutions assist in the study of composition, safety, efficacy, and mechanisms of microbial cell fragments products. These studies contribute to the development and application of microbial cell fragment-based postbiotics for animal feed.
Applications of Microbial Cell Fragments Postbiotics in Animals
Microbial cell fragments contain a variety of bioactive components that stimulate the immune system of animals. Some fragments also offer protection against foreign pathogens, enhance growth performance, and improve antioxidant status, among other benefits. Table. 2 presents the effects of select microbial cell fragments in animals.
Table. 2 Effects of microbial cell fragments on animals
| Animal Types | Microbial Cell Fragments | Effects |
|---|---|---|
| Pigs | Peptidoglycan derived from Bifidobacterium thermophilum | Oral administration of peptidoglycan induced a local immune response in the lamina propria of the small intestine of piglets. |
| Chickens | Peptidoglycan derived from Lactobacillus rhamnosus | It upregulated the expression of chicken β-defensin 9 without inducing an inflammatory response. |
| Trout | Peptidoglycan | Orally administered peptidoglycan enhanced the innate immune defenses of trout at mucosal surfaces. |
| Pigs | Lipoteichoic acid of Lactobacillus plantarum | It acted as an effector molecule to inhibit viral pathogen-induced inflammatory responses in porcine intestinal epithelial cells. |
| Pigs | Exopolysaccharides synthesized by Lactobacillus reuteri | It protected against enterotoxigenic Escherichia coli in piglets. |
| Chickens | Se-enriched exopolysaccharides | It improved growth performance, antioxidant status and immune function in broilers. |
Why Choose Us?
Wide range of internal and external analysis platforms to test the composition and nutritional content of diverse microbial cellular fragments.
Extensive animal models encompassing both in vivo and in vitro requirements, enabling animal-specific studies on the use of microbial cell fragments as postbiotics.
Knowledgeable staff with expertise in animal physiology and microbiology, committed to understanding your research needs and providing timely solutions.
BioVenic's research solution specializes in feed postbiotic development services for a wide range of complex microbial cell fragment components. Utilizing our feed analysis, animal metabolite analysis, animal nutrition and metabolomics analysis technologies, we can evaluate the safety and efficacy of various postbiotics. If you are interested in our microbial cellular debris solution for postbiotics in feed, kindly contact us with your research needs, and we will efficiently provide robust solutions for you.
Reference
- Zhong, Yifan, et al. "Gut health benefit and application of postbiotics in animal production." Journal of Animal Science and Biotechnology 13.1 (2022): 38. Under Open Access license CC BY 4.0, without modification.