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Precision Bovine Breeding
Genetic modification of animals is a crucial driving force for the sustainable development of the global livestock industry. The ability to target the inactivation of genes of interest, knock-in genes, or achieve allelic introgression without unwanted linkage resistance through the use of gene editing technologies provides a reliable scientific method for introducing superior genetic variation into cattle breeding programs. BioVenic offers comprehensive solutions for modifying the complete genome of cattle to enhance cattle health and welfare, improve product yield and quality, and support targeted breeding programs. We assist global customers in advancing precision breeding projects for farmed cattle.
Fig.1 Application of Precision Breeding Strategies for Cattle1,2.
One-stop Solution for Bovine Genetic Modification
Genetically improved breeding for bovine is more sustainable, permanent, and cumulative than traditional breeding. BioVenic's one-stop genetic modification solution caters to the diverse needs of researchers engaged in precision bovine breeding, facilitating the acceleration of genetic progress. The four main directions of gene editing, transgenesis, gene delivery, and target editing verification fully support the varied requirements in precision animal breeding research.
Flow Chart of One-stop Animal Gene Editing Solution
Precision Breeding in Bovine
Improvements brought about by precision breeding at the genetic level are heritable and more targeted. BioVenic has extensive project experience in molecular biology, animal genetics, and breeding. We continuously optimize technical processes in practice and are committed to providing professional and reliable experimental design and scientific data to customers. For precision breeding of bovine, the main research focuses on improving product yield and quality of dairy and beef cattle, cattle health, and welfare. Additionally, research aims to enhance reproductive ability and develop sterile receptors. Our scientific research team closely monitors cutting-edge trends and consistently updates the functional target information database to maintain the scientific research value of our service solutions.
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Health and Welfare
Precision gene-edited breeding can achieve permanent improvements without requiring ongoing investments in nutritional and animal health interventions. At the same time, precise breeding improvements for animal health and welfare significantly reduce time and costs. The most classic method of dehorning bulls involves knocking out key genes, which reduces the harm that animals cause to each other. The losses caused by typical infectious diseases, such as mad cow disease, can also be mitigated by targeting viral components for inactivation to improve resistance. -
Product Yield and Quality
Our precision cattle breeding services provide technical tools to research new breeds with greater economic benefits. Our project solutions enable sustainable agriculture and increased productivity to work hand in hand. BioVenic focuses on achieving excellent production performance, such as high feed utilization and high milk production, in order to identify the gene targets associated with these traits and edit them. At the same time, fewer high-yielding dairy cows or beef cattle are required to meet production needs and improve feed utilization, reducing the environmental impact of animal husbandry. It is worth mentioning that precise editing of allergen genes in milk through gene editing can help produce allergen-free milk. -
Reproduction or Sterility
Optimizing reproductive capacity and producing sterile bulls are key objectives in cattle breeding. BioVenic's precision cattle breeding solutions focus on exploring functional gene targets closely related to breeding traits such as milk production, litter size, etc. We utilize gene editing technology to achieve permanent heritable improvements in breeding.
| Traits | Gene | Gene ID | Functions |
|---|---|---|---|
| Production | MSTN | 281187 | Prevents excessive growth of muscle tissue at all stages of organism development. |
| MYF5 | 281335 | Affects the number and size of muscle fibers. | |
| MYOD1 | 281938 | Closely related to meat growth and development traits. | |
| FABP4 | 281759 | Involved in regulating triglyceride formation and fat breakdown. | |
| BLG | 280838 | Encodes β-lactoglobulin. | |
| DGAT1 | 100126245 | Key gene for milk production and encodes a crucial enzyme that regulates the primary pathway for triacylglycerol (TAG) synthesis in adipose tissue. | |
| Growth | GH | 280804 | Regulates growth and development. |
| POU1F1 | 282315 | Regulates GH, TSH and other genes to indirectly affect growth and development. | |
| Reproduce | NANOS2; nos2 | 100299090 | Related to germ cell development and maintenance of primordial germ cells (PGCs) and germline stem cells |
| SOX9 | 100336535 | Sex determination | |
| Resistance | PRNP | 281427 | Directly related to the occurrence of mad cow disease. |
| CD46; MCP | 280851 | Encodes the CD46 receptor, which is the primary cellular target of bovine viral diarrhea virus (BVDV). | |
| DMBT1; MUCIN | 404104 | Involved in skeletal muscle development during early myogenic stages; associated with susceptibility to bovine tuberculosis. | |
| NRAMP1 | 282470 | Encodes natural resistance-related macrophage proteins to enhance an individual's ability to resist disease | |
| CD18 | 281877 | Determines that the signal peptide of the adhesion protein on the surface of leukocytes is not cleaved, allowing it to bind to the leukotoxin produced by Mannheimia haemolytica. | |
| IARS | 509885 | Encodes Isoleucyl-tRNA synthetase (IARS), a single nucleotide substitution that causes Isoleucyl-tRNA synthetase syndrome. | |
| Welfare | PMEL; RPE1; SILV; PMEL17 | 281487 | Encodes a premelanosome protein directly linked to hair pigmentation as a potential adaptation to climate change. |
| POLLED allele | 281415 | Determines the hornless phenotype in cattle. | |
| PRLR | 281422 | SLICK1 mutations in PRLR result in shorter fur and enhanced thermoregulation. |
Why Choose Us?
By customizing precision cattle breeding scientific research services, you can achieve:
Capacity to maintain livestock biodiversity.
Enhance feed utilization and minimize waste.
Reduce greenhouse gas emissions and achieve environmentally friendly development.
Local climate adaptation enhances animal welfare.
Reduce antibiotic usage.
Improve resistance to prevalent diseases like foot-and-mouth disease virus (FMDV).
BioVenic has developed a comprehensive precision breeding platform for farm animals, offering tailored solutions for bovine. We utilize advanced molecular biology methods to investigate and decode the genetic blueprint of cattle. Through this process, we identify valuable genes that promote bovine health and productivity, boost disease resistance, and improve overall welfare. Our scientists are dedicated to meeting the increasing demand for nutritious food for ethically and sustainably raised animals through precision breeding. If you are seeking a partner to enhance cattle genetics precisely, please feel free to contact us.
References
- Mueller, Maci L., and Alison L. Van Eenennaam. "Synergistic power of genomic selection, assisted reproductive technologies, and gene editing to drive genetic improvement of cattle." CABI Agriculture and Bioscience 3.1 (2022): 13.
- Image retrieved from Fig 1 "Schematic illustrating the synergistic relationships between genomic selection (GS), assisted reproductive technologies (ART), and gene editing for the genetic improvement of cattle". Mueller, Maci L., et al., 2022, used under CC BY 4.0. The original image was modified by changing title to "Application of Precision Breeding Strategies for Cattle".