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Precision Sheep Breeding
As a typical farm animal species, sheep have significant economic value due to their meat, milk, fiber, and other by-products. Transgenic technology and gene editing have been applied to sheep to improve their quality. BioVenic specializes in various technologies for genome improvement, such as CRISPR, which is widely used in the field of genome editing. Our laboratory team utilizes these tools to genetically edit sheep based on customers' specific requirements, offering dependable solutions for researching gene functionality, enhancing animal breeding, altering the composition of milk, and boosting sheep disease resistance. Our one-stop precision sheep breeding solution integrates genome engineering, molecular biology, and genetic breeding. BioVenic is dedicated to addressing customers' scientific research challenges by identifying, utilizing, and even integrating exceptional sheep traits.
Fig.1 Application of Sheep Genome Editing in Breeding1,2.
One-stop Solution Sheep Genetic Modification
Based on genetic modification technology, we can alter specific characteristics of sheep or introduce traits that cannot be achieved through natural evolution. This can effectively enhance sheep productivity, decrease feeding costs, and enhance welfare and health. On the other hand, the animal genome editing service supports the creation of cell or animal models for studying any metabolism-related mechanisms. BioVenic has established a precision sheep breeding technology platform based on our extensive experience in animal genetic modification. We utilize molecular techniques such as genome editing and recombinant DNA constructs to introduce specific genes into sheep.
Flow Chart of One-stop Animal Gene Editing Solution
Sheep Genomic Breeding Database
BioVenic has constructed a genome selection reference library with extensive coverage by conducting precise large-scale trait measurements and sequencing the sheep genome. Our research team and the bioinformatics team have collectively gathered hundreds of thousands of phenotypic data points along with corresponding genomic information. Utilizing big data analytics, we have successfully created a genetic variation map focusing on key genetic variation sites within the sheep population. Sheep genome breeding database facilitates the identification of key genes associated with important economic traits such as feed conversion rate, growth rate, tail fat deposition, and muscle development. It also meets the needs for genetic assessment in the areas of genomic selective breeding, gene mapping of important economic traits, and breed identification.
Precision Breeding in Sheep
The direction of precision breeding of sheep can be roughly divided into the development of disease-resistant varieties, promotion of muscle and wool growth, molecular manipulation of sheep milk components, and improvement of reproductive performance. Through years of scientific research experience in the fields of animal genetics and molecular biology, BioVenic has identified gene targets closely associated with sheep economic traits. Our research technical team conducts in-depth analysis of the sheep functional genome to provide strong theoretical support for program design and development. This ensures that customers' diverse breeding needs are met through customized precision sheep breeding solutions.
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Disease-resistant Variety Development
BioVenic offers dependable gene editing and transgenic-resistant sheep breeding solutions to scientific researchers worldwide. This not only provides farm animals with more economically valuable breeds and a potential source of heritable disease resistance traits but also offers a good model for studying and understanding the pathogenesis of diseases. We support clients in achieving their research goals related to enhancing sheep health and welfare. -
Muscle and Wool Growth Promotion
Sheep are a valuable source of fiber and are economically beneficial due to their traits such as weight gain and accelerated growth. BioVenic integrates genetic targets related to growth and fiber quality and quantity, providing gene editing to advance breeding goals that accelerate agricultural production. -
Milk Components Molecular Manipulation
BioVenic's primary focus in precision sheep breeding services involves utilizing gene editing and transgenic technologies to manipulate the molecular components of milk. This not only supports the use of transgenic technology and gene knock-in to enrich milk ingredients but also endorses the suppression of protein expression or gene knock-out to remove allergens in dairy products. -
Reproductive Performance Improvement
BioVenic's precision breeding program offers robust scientific research tools to enhance sheep reproductive performance. We utilize gene editing tools to introduce desirable traits associated with fertility, such as litter size, into sheep. This approach enables us to selectively breed for these traits, ultimately enhancing reproductive performance.
| Traits | Gene | Gene ID | Functions |
|---|---|---|---|
| Production | MSTN | 443449 | Prevents excessive growth of muscle tissue at all stages of organism development. |
| DGAT1 | 100126245 | Key genes for milk production and encodes key enzymes that control the main pathway for TAG synthesis in adipose tissue. | |
| ASIP; ASP | 100127221 | Encodes the Agouti signaling protein responsible for sheep coat color phenotypes. | |
| FGF5 | 100642180 | Key regulator of mammalian hair length. | |
| CFTR | 443347 | Encodes a CF transmembrane conductance regulator and is associated with the development of cystic fibrosis. | |
| Growth | SOCS2 | 101115017 | Encodes suppressor of cytokine signaling 2 (SOCS2), which is closely related to body weight and body development in sheep. |
| BCO2 | 100286796 | Related to the yellow fat characteristics of sheep. | |
| LPL | 443408 | Encodes lipoprotein lipase, which in turn affects fat metabolism. | |
| Reproduce | BMPR1B; ALK6; FecB; BMPR-IB | 443454 | The multiple pregnancy gene, encoding the type 1B bone morphogenetic protein receptor, has a significant impact on fertility in many sheep breeds. |
| Resistance | PRNP; Prp; SIP; PRPC; prion; AltPrP | 493887 | Encodes a membrane glycoprotein on the outer surface of neurons, lymphocytes, and other cells, and is directly involved in the development of prion-mediated diseases. |
Why Choose Us?
Supported by the self-constructed high-quality library of sheep phenotype and gene target information.
Precise mastery of mammalian gene editing and transgenic technologies.
Customization of high-quality precision sheep breeding solutions.
Experts in the fields of animal genetics, breeding, and molecular biology provide technical support throughout the process.
BioVenic offers precision breeding and customized genome modification services to global customers in the scientific fields of basic sheep genome research, animal husbandry development, and disease mechanism research. We utilize cutting-edge gene editing and transgenic technologies to develop comprehensive and scientifically sound project plans. We employ biological methods to deepen our understanding of target genes, their corresponding phenotypes, and functions. If you are conducting research related to phenotyping in sheep, please contact us to unlock the powerful potential of genome engineering through precision breeding solutions.
References
- Kalds, Peter, et al. "Sheep and goat genome engineering: from random transgenesis to the CRISPR era." Frontiers in Genetics 10 (2019): 750.
- Image retrieved from Figure 2 "Schematic representation of practical and likely pathways of genetic modification in sheep and goats". Kalds, Peter, et al., 2019, used under CC BY 4.0. The original image was modified by changing title to "Application of Sheep Genome Editing in Breeding".