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CRISPR gRNA Synthesis in Precision Animal Breeding
CRISPR genome editing simplifies editing operations by replacing guide RNAs at different editing sites. The quality of the gRNA determines whether the entire editing process can be carried out correctly and efficiently. BioVenic offers a range of methods for synthesizing gRNA with high purity, low toxicity, and accurate sequence. These services are tailored to meet the specific needs of customers and support the research and development in precision animal breeding.
Fig.1 Schematic Diagram of CRISPR gRNA Synthesis. (BioVenic Original)
Featured gRNA Synthesis Services
High-quality gRNA is crucial for ensuring the stable operation of the CRISPR genome editing system in precision animal breeding. BioVenic customizes gRNA synthesis service according to your specific research requirements. We help to choose the proper methods of gRNA synthesis and delivery standards for different scientific research projects.
- gRNA Modification
gRNAs in different editing systems are modified in different forms in order to improve their stability and targeting. We ensure that gRNAs are synthesized and delivered to you with high accuracy and purity level, while its stability and specificity are optimized by beginning and ending modification.
- gRNA Purification
BioVenic offers different options of various synthesis methods and product states according to the requirements of your scientific research project. We provide gRNA purification services, such as desalted gRNA, to ensure the safety and effectiveness of animal genome editing process.
- Methods of gRNA Synthesis
| Methods | Synthesis | Advantages |
|---|---|---|
| Plasmid-expressed sgRNA | The sgRNA sequence is first cloned into a plasmid vector and then introduced into the cell by transfection. | Suitable for high-throughput gene editing. |
| In vitro Transcribed sgRNA | sgRNAs are first transcribed from DNA templates by RNA polymerase and then purified before experiments. | A basic quality control system, higher gene editing efficiency compared with plasmid sgRNA. |
| Chemically Synthesized sgRNA | Directly synthesized by chemical methods. | Short preparation cycle, chemical modification, no cytotoxicity, high-efficiency gene editing. |
Other gRNA-related Services
BioVenic has an industry-leading ability to synthesize gRNA and supports custom synthesis of full sequences. We adhere to strict production and quality control standards for every customized synthesis project, which is also an effective guarantee for the stable quality of gRNA. Simultaneously, BioVenic is committed to providing comprehensive personalized gRNA services to global customers who have gene editing needs in the field of precision animal breeding.
gRNA design and synthesis.
Why Choose Us?
Customized synthesis solutions with high adaptability and efficiency according to customer needs.
High-quality synthetic sequences to ensure targeting efficiency.
A quality control system precisely matched to your research stage.
BioVenic relies on its professional scientific research team in animal breeding and genome editing and experimental platforms, such as high-throughput gene synthesis and sequencing, to provide customers with multiple quality-assured gRNA synthesis services. We aim to become your dependable partner in the field of animal scientific research with our independent production lines, high-purity products, rigorous testing, and experienced project management. Please feel free to contact us for customization of your gRNA synthesis services.