Feed Patulin Solution

R&D Solutions

Get a quote

We're excited to learn more about your project and provide you with a customized quote tailored to your needs. Please fill out the form below, and we'll get back to you as soon as possible.

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Feed Patulin Solution

Inquiry Now

Sources of Patulin Impacts of Patulin on Animals Feed Patulin Solutions Service Workflow Why Choose Us?

Patulin, a harmful chemical contaminant, is synthesized by various types of microscopic filamentous fungi. It is categorized among a select group of mycotoxins, alongside aflatoxins, ochratoxin A, zearalenone, fumonisins, and trichothecenes, with regulated levels in food across numerous global jurisdictions. BioVenic offers comprehensive solutions to address patulin presence in animal feed, ensuring animal health protection. Our services encompass patulin analysis, formulation of feed additives to counter patulin, biological detoxification methods for patulin, as well as research solutions tailored to animals affected by patulin contamination.

Sources of Patulin

Patulin, also known as 4-hydroxy-4H-furo[3,2c]pyran-2(6H)-one, is synthesized by various molds. Initially identified as an antimicrobial agent in the 1940s from Penicillium patulum, it is a metabolic byproduct produced by numerous microscopic filamentous fungi across different genera like Bysochlamys, Eupenicillium, Penicillium, Aspergillus, and Peacylomyces. This mycotoxin is notably prevalent in apples, apricots, grapes, grapefruit, peaches, pears, olives, and various cereal grains.

Impacts of Patulin on Animals

Patulin has been documented as a genotoxic, reprotoxic, embryotoxic, and immunosuppressive substance. It adversely affects several key biochemical parameters such as AT-Pase, alkaline phosphatase, aldolase, and hexokinase activities. The following table outlines the effects of patulin on different animal types:

Table. 1 Impacts of patulin on animals

Animal Type	Effects
Pigs	Patulin triggers mild toxic reactions in porcine intestinal tissues.
Cattle	Linked with fatal neurotoxicosis in cattle. Acts as a potent inhibitor of bovine peripheral blood mononuclear cell proliferation.
Poultry	Patulin toxicosis leads to variations in moisture, fat, and vitamin A levels in laying hen livers. Results in reduced calcium content of eggshells and alters egg shape.
Dogs	Dogs exhibit severe symptoms from patulin exposure, particularly affecting the lungs. Common manifestations include lethargy, anorexia, hematemesis, diarrhea, pulmonary hemorrhages, edema, and gastrointestinal tract bleeding when administered doses of 10 mg/kg or higher.

Feed Patulin Solutions

Through our mycotoxin analysis platform, animal models, and animal nutrition metabolite analysis platforms, we have crafted a range of solutions addressing feed patulin. These solutions aim to assist animal nutrition researchers in overcoming challenges encountered during patulin investigations.

Patulin Analysis Solutions

Patulin, a molecule with low molecular weight and high polarity, poses numerous analytical hurdles during detection. Utilizing HPLC-UV as the predominant method, we deliver proficient testing services and products for patulin analysis in feed samples, products of animal origin, and other specimens. Our solutions encompass immunological assays like ELISA and chromatographic techniques such as HPLC-UV, LC-MS/MS, and GC-MS/MS. Additionally, we offer avenues for pioneering analytical method development to detect patulin efficiently.

Feed Additive Development for Patulin

Primarily sourced from bioactive compound extracts acting as free radical scavengers, feed additives aim to mitigate patulin toxicity. A selection of potential feed additives for alleviating the detrimental impacts of patulin is outlined in Table. 2. Our feed additive development solution serves as a resource for animal nutrition researchers, facilitating the identification, evaluation, and advancement of feed additives tailored to combat patulin effects.

Table. 2 Potential feed additives or treating patulin

Feed Additive	Descriptions
Green tea polyphenols (GTP)	They inhibit patulin's impact on ALT and AST serum levels and can prevent patulin-induced TBARS in a dose-dependent manner.
Green tea leaves (GTL)	Offer protection against liver tissue damage and protein expression in patulin-exposed mice, reliant on antioxidant properties.
Crocin (CRO)	Reduces patulin-induced liver and kidney damage by mitigating lipid peroxidation, protein oxidation, and reinstating redox equilibrium via modulation of endogenous antioxidant enzymes.
Vitamin supplements	Vitamin E supplementation significantly reduces cell death in HepG2 cells treated with patulin. Vitamin C exhibits potential in counteracting patulin's toxic effects.
Selenium compounds	Provide protective effects against patulin-induced neurotoxicity. They demonstrate notable antioxidant effects in the brain and ameliorate patulin-induced oxidative harm.
Probiotics	Certain lactic acid bacteria strains such as L. rhamnosus, L. brevis, L. plantarum, and B. longum can eliminate PAT in experimental settings. They hold promise in rectifying patulin-induced intestinal damage, addressing issues like intestinal microbiota and mucosal dysregulation.

Development of Biological Detoxification for Patulin in Animal Feed

Our approach to addressing patulin contamination in animal feed involves two main strategies: adsorption and degradation. By leveraging microbial organisms and enzymes, we aim to effectively remove patulin from animal feed. Furthermore, we conduct comprehensive assessments of the efficacy of biological detoxification both in vitro and using animal models.

Animal Research Solutions for Patulin

We provide a diverse array of animal models, encompassing both in vitro and in vivo studies, to investigate the impact of patulin on animals and elucidate the underlying mechanisms affecting animal health. Our expertise in animal nutritional metabolite assays and omics solutions also serves as a valuable reference for refining biodetoxification processes and developing feed additives.

Service Workflow of Feed Patulin Solution

Why Choose Us?

Advanced Detection Technologies

Our cutting-edge detection platform ensures rapid and precise identification of patulin across various samples, facilitating the innovation of novel detection methodologies.

Tailored Animal Models

We cater to the specific needs of in vitro and in vivo investigations, offering customized solutions for a variety of livestock, poultry, and companion animals.

High-Throughput Omics Techniques

Leveraging metabolomics, proteomics, microbiomics, and similar methodologies, we provide insights into the effects of feed additives and biological detoxification on mitigating the adverse impacts of patulin.

Our dedicated technical support team constantly monitors the latest advancements in feed mycotoxin research. Based on the unique properties of feed patulin, BioVenic develops comprehensive solutions that include detection of patulin in feed, development of feed additives and bioprocesses, and validation through animal model studies. Should you be interested in our Feed Patulin Solution, please don't hesitate to contact us. We are committed to understanding your requirements and delivering tailored services to meet your specific needs.