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Feed Enzymes-Phytases
Phytase is an enzyme that functions as a phosphatase by removing orthophosphate groups from the inositol ring of phytic acid. This process creates free inorganic phosphorus and a range of lower phosphoric esters as intermediate products. By reducing phytates' attraction to various cations, phytase effectively breaks down indigestible phytate present in plant materials. BioVenic specializes in solutions for the development of phytases as feed enzyme supplements, offering services such as the cultivation of phytase-producing strains, optimizing phytase fermentation, creating phytase feed additives, researching the effects of phytase application in animals, and more.
Advancements in Feed Phytases Development and Optimization
- Exploration of Phytases Resources
While phytases are found in animals, plants, fungi, and bacteria, fungi like Aspergillus niger are notably rich sources. Through cutting-edge sequencing techniques, we analyze phytase genes from diverse origins to provide essential data for further research.
- Examination of Enzyme Properties
Each source of phytase possesses unique enzymatic traits. We offer a range of products and services for enzyme activity assays, aiding in the study of phytase properties such as optimal temperature, thermal stability, acid resistance, and the impact of metal ions on enzyme function.
- Study of Phytases Catalytic Mechanisms
Variations exist in the structures and mechanisms of phytases. Our research platform conducts comprehensive studies on phytase protein structures to uncover their catalytic mechanisms, facilitating the development of superior phytases.
- Enzyme Modification
Enhancing phytases' thermal stability and acid resistance is crucial for its efficacy in animal feed. Through genetic and protein engineering techniques, we can modify phytase to produce novel variants with superior properties.
- Fermentation Optimization
Fermentation is key to phytase production, with solid-state and liquid fermentation being common methods. By optimizing fermentation conditions for specific phytase-producing strains, we enhance the production efficiency through medium, time, and inoculum size adjustments.
Exploration of Phytases Application in Feed
Phytase liberates phosphorus from phytate in animals, enhancing phosphorus utilization in plant-based feeds. Our feed analysis services can assess phosphorus levels and other components, shedding light on phytase's impact on phosphorus digestibility.
- In Vitro Simulated Digestion
Through our diverse animal nutrition and metabolism in vitro models, we facilitate simulated digestion studies on various sources and concentrations of phytase for tailored diets. This approach aids in the development of efficient and species-specific phytase products.
- In Vivo Animal Studies
The advancement of novel phytase enzymes as feed supplements necessitates animal trials to establish a scientific foundation. Utilizing our in vivo animal models, we analyze the impact of phytase feed additives on animals. Our primary focus areas include animal growth metrics, nutrient absorption rates, and the levels of nitrogen, phosphorus, and other waste products in fecal matter. Phytase effectiveness can be evaluated through the following metrics:
- Ileal phytate phosphorus degradation
- Total tract phosphorus digestibility and retention
- Bone ash content
- Performance metrics.
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Feed Phytases Development
Utilizing processes such as strain selection, fermentation technologies, post-processing, and animal trials, we assist clients in creating a range of phytase products in various forms. Our focus in phytase product development lies in achieving both cost-effectiveness and species-specific formulations.
Application Effects of Phytases in Animal Feed
The efficacy of supplemented phytases in the gastrointestinal tract can be influenced by the animal species and age. The application effects of different phytases in animals are detailed in the following table:
Table. 1 Application effects of some phytases in animals
| Animals | Phytase source | Effects |
|---|---|---|
| Pigs | Microbial | Improved growth performance and increased mineral digestibility (N, P, Ca, Mg, Cu, Zn). Decreased phosphorus and copper excretion in pig manure. |
| Peniophora lycii phytase fermented in a genetically modified Aspergillus oryzae strain | Enhanced phosphorus digestibility in sow diets, along with improved ash, calcium, magnesium, sodium, potassium, copper, and zinc digestibility. | |
| Aspergillus niger | Reduced energy expenditure in the digestive tract and boosted metabolic activity in young piglets' visceral organs. | |
| Chickens | Escherichia coli phytase expressed in Schizosaccaromyces pombe | Enhanced growth, bone mineralization, and phosphorus utilization in broiler chicks. |
| Genetically modified Aspergillus niger strain | Improved growth, production metrics, and tibia parameters in laying hens. | |
| Fish | Aspergillus niger | Enhanced phytate phosphorus bioavailability in channel catfish. |
| Microbial | Increased serum calcium and phosphorus levels. Elevated body protein and lipid content, with improved nutrient utilization in Nile tilapia. | |
| Aspergillus niger | Improved phosphorus availability shown by significantly higher apparent phosphorus availability and bone ash content, in addition to elevated plasma and body phosphorus concentrations. Reduced phosphorus load in rainbow trout fed a soybean protein concentrate-based diet. | |
| Dogs | - | Increased phosphorus digestibility coefficient in a vegetable-based diet for dogs. Decreased hexa-inositol-phosphates without affecting lower inositol phosphates. |
| Horses | Aspergillus niger | Enhanced apparent calcium digestibility, potentially beneficial for horses on phytate-rich diets. |
Animal Feed Phytases Development Workflow
Why Choose Us?
Our research team boasts extensive experience in animal nutrition and feed enzyme development, ensuring that we offer practical solutions tailored to your requirements.
We provide a range of in vivo and in vitro animal models essential for conducting thorough research on phytase applications. These models yield crucial insights into the effects of phytase applications.
Our solutions encompass a diverse array of services aimed at streamlining your research processes and overcoming challenges effectively.
By employing our comprehensive research platform, you gain access to the ability to develop phytases from multiple sources for various animal species. BioVenic's advanced technologies in enzyme development, enzyme application effect research, and enzyme product development equip you to create top-tier phytase products for animal feed. Should you have any research requirements concerning feed phytase development, do not hesitate to contact us. Our dedicated team is ready to understand your research objectives and provide robust solutions tailored to your needs.