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Feed Enzymes-Proteolytic Enzymes
Proteolytic enzymes, commonly referred to as proteases, play an important role in the breakdown of proteins. Endogenous proteases play an important role in all metabolic processes in the animal body. Exogenous proteases can be used in animal nutrition either in the processing of feed ingredients or directly as feed additives. Including proteases in animal feed can improve the digestion and utilization of protein, optimize the utilization of other nutrients, improve growth performance and reduce environmental impact. These feed additive proteases are usually derived from plants or microbes. BioVenic offers comprehensive services for the development and optimization of feed proteases tailored to specific requirements.
Feed Proteolytic Enzymes Development and Optimization
- Genetic Investigation of Proteolytic Enzymes
Various microbial proteases exhibit favorable characteristics for feed additive development. Leveraging our genetic research platform, we conduct in-depth analyses, bioinformatics assessments, and recombinant expression of microbial protease genes. This approach aids researchers in creating innovative proteases from a genetic and molecular biology standpoint.
- Evaluation of Enzyme Characteristics
Our solutions assist in evaluating the substrate degradation capacity, pH and temperature stability, enzyme activity, resistance to anti-nutritional factors like trypsin inhibitors, and potential synergistic interactions with other feed enzymes. Understanding these enzymatic properties provides a foundational understanding for protease application.
- Study of Proteolytic Enzymes Catalytic Mechanisms
Through our advanced technological platform, we delve into the molecular structure of enzymes using various methodologies. This exploration sheds light on the catalytic mechanisms of proteases at a microscopic level.
- Enzyme Modification
Through genetic manipulations that optimize protease structure and expression in strains, our solution facilitates the generation of high-performance protease-expressing strains tailored to diverse animal feed applications.
- Fermentation Optimization
By refining fermentation inoculum, culture media, and conditions, we streamline protease production processes, trimming costs, and bolstering yields.
Feed Application Study for Proteolytic Enzymes
Proteases break down proteins in feed into smaller peptides or amino acids. Our feed analysis technology quantifies protein components and detects peptides and amino acids formed by protease activity. This analytical insight aids researchers in comprehending the mechanisms behind protease action as an animal feed additive.
- In Vitro Simulated Digestion
Through our state-of-the-art animal nutrition and metabolism in vitro models, we simulate the digestive tract environments of specific animals. Paired with our feed analysis technology, this setup enables the examination of how the inclusion of novel proteases impacts specific feeds. This analysis forms a theoretical foundation for the integration of proteases in animal feed applications.
- In Vivo Animal Studies
Proteases exhibit varying effects on animals due to their diverse structures and functionalities. Our diverse range of in vivo animal models empowers researchers to explore the impacts of different protease doses, sources, and formulations on specific animal species, age groups, and growth stages. Leveraging our animal nutrition and metabolism analysis platform and omics solution, we uncover the distinct effects of various proteases and evaluate their practical utility in animal nutrition.
Feed Proteolytic Enzyme Development
Our solutions for the development of feed protease products offer comprehensive technical assistance for strain improvement, fermentation strategies, product formulation, dosage determination, stability assessments, and other critical aspects tailored to the specific research requirements of our clients. By leveraging our feed protease additive product development solutions, we aim to optimize production costs without compromising on the excellence and consistency of the final product.
Application Effects of Proteolytic Enzymes in Animal Feed
Due to their catalytic capabilities, proteases can compensate for the deficiency of endogenous proteases in animals, enhancing their protein digestion efficiency. Various proteases exhibit distinct catalytic properties, resulting in diverse application effects when used as animal feed additives. The subsequent table outlines the application effects of different proteolytic enzymes in various animals.
Table. 1 Application effects of some proteolytic enzymes in animals
| Animals | Proteolytic enzymes | Effects |
|---|---|---|
| Pigs | Alkaline serine endopeptidase produced from bacterial fermentation product | Improved growth rate, enhanced nutrient digestibility, and reduced fecal NH3 emission in weanling pigs. |
| Protease from Bacillus licheniformis | Increased apparent ileal digestibility of gross energy in grower-finisher pigs. | |
| Chickens | Commercial protease | Positive response in broiler chickens, safe addition on top of their diets. |
| Protease from Bacillus licheniformis containing transcribed genes from Nocardiopsis prasina | Enhanced digestibility of crude protein and key amino acids, maintaining performance in laying hens. | |
| Cattle | Commercial protease | Showed anticipated positive effects on total-tract nutrient digestibility, influenced by protease dosage. Combination with amylase did not significantly enhance milk production. |
| Fish | - | Improved growth, digestibility, immunity, and flesh quality in gibel carp. |
| Fluid-bed technology coated protease | Supplementation in low protein diets resulted in protein savings, enhanced growth, feed efficiency, and nutrient digestibility without adverse health effects in juvenile Gibel carp. |
Animal Feed Proteolytic Enzymes Development Workflow
Why Choose Us?
Our solutions are tailored to meet the specific research requirements of our customers, prioritizing both practicality and innovation in protease development.
We possess a diverse array of in vivo and in vitro animal models, allowing for a comprehensive exploration of the effects of proteases on animals from multiple perspectives.
Our research team places great importance on internal and external collaborations, enhancing our customer service capabilities through effective communication channels.
As experts in animal nutrition, we have extensively researched every aspect of the animal feed protease development process. BioVenic's solutions encompass enzyme development investigations, studies on protease application effects, and protease product development strategies. For further information on our offerings or to discuss your needs, please don't hesitate to contact us. We are dedicated to understanding your requirements through friendly interactions and providing tailored solutions to suit your needs.