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Feline Metabolic Disorder Model Development

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Background Metabolic Disorder Model Development Common Metabolic Disorders in Cats Applications Why Choose Us?

Veterinary researchers focused on veterinary nutrition share concerns about the health and welfare of their animals, particularly in relation to nutritional metabolic disorders in cats. Feline metabolic disorder research has garnered significant attention as a major contributor to cat health and welfare. At BioVenic's integrated technology and knowledge platform, we provide an all-in-one solution for cat nutrition and Metabolic Disorder Animal Model Development. Our services encompass reliable model construction solutions, testing and analysis services, and more, to support cat nutrition research.

Background

Nutrient metabolism disorders in cats can stem from both genetic and environmental factors. Cats of different breeds possess distinct genetic traits, and the absence or mutation of certain enzymes can disrupt nutrient metabolism, resulting in metabolic disorders. Other risk factors include diet, age, gender, indoor confinement, physical inactivity, and various environmental factors. The occurrence of nutritional metabolic disorders in cats can be determined through specific test indicators or subjective judgment criteria. Nutritional imbalances can have detrimental effects on cat health, potentially leading to disease. Developing models of cat nutrient metabolism is crucial for enhancing cat health and discovering new nutritional strategies or treatments for specific disorders.

Feline Metabolic Disorder Model Development

  • Development of Gene-Induced Feline Metabolic Disorder Models

Different cat breeds display varying susceptibilities to nutritional metabolic disorders. For instance, the Burmese breed has a fivefold increased risk of type 2 diabetes compared to other purebred cats. With our genetic testing platform, researchers can select suitable cat breeds for modeling at the genetic level. The diverse genetic analysis platform also facilitates the exploration of mechanisms underlying nutritional metabolic disorders in cats, providing valuable insights.

  • Development of Diet-Induced Feline Metabolic Disorder Models

Diet, in conjunction with genetics, plays a crucial role in the development of metabolic disorders in cats. By altering dietary composition, such as carbohydrate and fat content, nutritionists can observe changes in behavioral and biochemical indicators of metabolic disorders influenced by diet.

  • Evaluation of Biomarkers in Feline Metabolic Disorder Models

An assortment of metabolites can serve as biomarkers for metabolic disorders in cats. Our services enable the detection of biomarkers associated with each metabolic disorder or disease. Additionally, our assay development services assist in creating assays for feline metabolites, ultimately validating your feline nutritional metabolic disease model for further application research.

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Common Metabolic Disorders in Cats

Metabolic Disorders Causes Indicators
Type 2 diabetes Insufficient insulin secretion from pancreatic β cells resulting in persistent hyperglycemia.
  • Islet amyloid and loss of beta-cell mass.
  • Weight loss despite a good appetite, increased thirst and urination.
  • Elevated blood and urine glucose level.
Obesity Energy imbalance: Reduced energy expenditure and enhanced energy intake.
  • Body condition score (BCS).
  • Body weight, girth, fat mass, lean mass.
Hyperlipidemia Abnormal lipid metabolism (inherited or acquired).
  • Triglycerides greater than 100 mg/dL.
  • Cholesterol greater than 200 mg/dL.
  • Serum turbidity.
  • Lipoproteins (chylomicrons, VLDL, LDL, HDL2, HDL3).
Hypocalcemia Calcium deficiency, elevated phosphate levels, or poor functioning of the parathyroid gland.
  • In animals less than 6 months, total serum calcium concentration <7 mg/dL, ionized serum calcium concentration < 1.1 mmol/L.
Hypoglycemia Insulin administration, missing or delaying meals, change in diet or amount of food fed.
  • Blurred vision, disorientation and confusion.
  • Blood glucose falls below 60 mg/dL.

Applications of Feline Metabolic Disorder Models

  • Evaluation of Feline Nutritional Strategies

To develop functional diets for obese cats, several nutritional strategies, such as reducing dietary fat and carbohydrate content, have been employed. Our feline metabolic disorder modeling service simplifies model construction and validation for nutritional strategy developers, ensuring the effectiveness of these strategies.

  • Exploration of Mechanisms in Feline Metabolic Disorders

Through our genetic and metabolite testing platform, researchers in the field of feline nutritional and metabolic disorders gain a molecular-level understanding of the associated mechanisms. This knowledge facilitates the development of new preventive and therapeutic tools.

Why Choose Us?

We have a deep understanding of the risks associated with nutritional metabolic diseases in companion animals, particularly cats, and we are dedicated to offering comprehensive research services in cat nutrition.

Our extensive range of products and services is specifically designed for cats, and we have the ability to provide customized solutions to meet your unique requirements.

Our attentive team takes pride in fostering sincere communication and ensuring a thorough understanding of your research needs.

Our focus lies on staying up to date with the latest trends and advancements in feline nutrition research. We are dedicated to delivering cutting-edge insights into the field of cat nutrition, addressing the most relevant and current topics.

BioVenic firmly believes that open and meaningful communication is the foundation of exceptional service. If you need assistance developing a gene- or diet-induced feline metabolic disorder model, or evaluating and applying your feline metabolic disorder model to your feline nutrition research, please don't hesitate to contact us. Our enthusiastic team is eager to gain a comprehensive understanding of your needs and provide the necessary support.

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