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Fully Feline Antibody Development
Felines are better suited to therapeutic antibodies that are entirely derived from feline gene sequences, free from any heterologous antibody components. BioVenic specializes in providing comprehensive development services for fully feline antibodies. We have established advanced platforms such as transgenic animal model, phage display, and single B cell to aid in fully feline antibody development, assisting in minimizing the risks associated with heterologous antibodies.
Fully Feline Antibody Development Based on Hybridoma Technology
Hybridoma technology remains a cornerstone in feline therapeutic antibody development. Hybridoma involves the fusion of feline B-cells with myeloma cells, creating hybrid cells that can produce monoclonal antibodies. These antibodies are fully feline, ensuring high compatibility and reduced risk of immunogenicity in feline patients. Our services include custom-design to elicit robust immune responses in cats, fusion of feline B-cells with myeloma cells to produce stable monoclonal antibody-secreting cell lines, as well as identifying and validating high-performance feline monoclonal antibodies for preclinical therapeutic development.
Fully Feline Antibody Development Based on Phage Display
BioVenic utilizes the innovative phage display technique to provide a fully feline antibody development service. This method removes the need for cat immunization, placing a high priority on the welfare of animals used in the development. The naïve antibody library exhibits no predisposition toward specific targets and serves as a versatile resource for isolating antibodies against a wide array of antigens. Our team specializes in providing the service for construct such naïve antibody libraries that have the capacity of 1010 variants, offering an extensive repertoire of variants for diverse applications.
Fully Feline Antibody Development Based on Single B-Cell Technology
BioVenic has established a single B cell platform for fully feline antibody development. Our team utilizes advanced techniques to efficiently isolate and screen positive B cells from immunized felines. The target antibody gene sequences are cloned into expression vectors and expressed in specialized host cells. We also provide antibody affinity assays to ensure that the antibody samples have high specificity and affinity, and are completely derived from feline sources, thereby minimizing the risk of immunogenicity.
Fully Feline Antibody Development Based on Transgenic Animal Model
Fig.1 How to get the fully feline antibody? (BioVenic Original)
BioVenic employs cutting-edge gene editing techniques to establish a transgenic mouse-based platform for generating fully feline antibodies. Our expert team incorporates feline antibody genes into the mouse genome, ensuring their stable integration into the mouse chromosomes. Leveraging our hybridoma technology, we then guide you through the process of therapeutic antibody development to produce antibodies that are entirely derived from feline sources. In the process of mouse immunization, BioVenic offers a diverse array of antigens, encompassing proteins, peptides, DNA, mRNA, and VLPs. We meticulously design immunization protocols considering the specific characteristics of antigens, the chosen immunization route, and their potential to elicit an immune response.
Why Choose Us?
Diverse fully feline antibody development technology platforms based on transgenic mice, phage display and single B cell enrich your options.
Our end-to-end service accelerates project progression, from construction to expression and affinity assays, offering faster and more convenient development services.
Our technical team screens individual B cells using high throughput screening methods to efficiently assist in fully feline antibody development.
BioVenic is dedicated to advancing veterinary medicine through innovative and species-specific therapeutic solutions. Join us in revolutionizing cat healthcare with our cutting-edge technologes. We offer comprehensive services for fully feline antibody development, including phage display, transgenic animal model, and single B-cell technologies. Feel free to reach out to us, if you have any needs about fully feline antibody development.