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Veterinary Vaccine Adjuvant Development
Adjuvants refer to agents added to vaccines or used in conjunction with vaccine antigens to increase or enhance the antigen-specific immune response of animals. Compared to traditional veterinary vaccines, new types of vaccines such as nucleic acid vaccines, recombinant vaccines, and subunit vaccines are relatively safe, but they often have lower immunogenicity. Therefore, the development of efficient, safe, and effective adjuvants to enhance the specific immune response in animal organisms is of great importance. BioVenic offers veterinary vaccine adjuvant development services, allowing for adjustments to the adjuvant formulation based on your preferences.
Common Veterinary Vaccine Adjuvants
| Types | Description | Advantages | Limitations |
|---|---|---|---|
| Mineral Salts |
Includes alum and calcium phosphate. Resulting in an immune response to the Th1 pathway. |
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| Emulsions |
Including oil-in-water emulsions and water-in-oil emulsions. Immiscible liquids are mixed together to form emulsions that are organized into small droplets dispersed in another droplet and stabilized by an interfacial surfactant layer. |
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| Immunoactive Compounds |
Includes cytokines, saponins, and polymers. Used as veterinary vaccine adjuvants for their ability to stimulate immune responses. |
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| Toll-Like Receptor Agonists | Activation of TLR can facilitate the induction of antigen-specific immunity by inducing the expression of certain cytokines involved in T-cell differentiation. |
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Fig.1 How different types of emulsions work. 1
Our Services
Adjuvant Selection
BioVenic offers adjuvant selection services in veterinary vaccine development. Tailored to specific requirements and target animal species, we meticulously select and optimize suitable adjuvants. Considering various factors such as animal welfare, immune response type, and vaccine objectives, we ensure the chosen adjuvants harmonize with the vaccine formulation, maximizing the efficacy of the immune response.
| Consideration of Target Animal Characteristics | According to the physiological characteristics, immune system response, and living environment of target animals, and considering the impact of adjuvant on the safety of vaccinated animals. |
| Matching Vaccine Types | Ensuring compatibility and optimal effectiveness for different types of veterinary vaccines, such as inactivated vaccines, subunit vaccines, etc. |
| Optimizing Immune Response | Optimizing the immune response, including enhancing antibody production and activating cell-mediated immunity. |
| Sustained Protective Effects | Providing sustained protective effects, thereby extending the immune efficacy of veterinary vaccines. |
Customized Combination
Combining different adjuvants in a vaccine formulation can enhance its efficacy. An ideal adjuvant should be capable of efficiently delivering the antigen in its native conformation to antigen-presenting cells, stimulating the secretion of appropriate cytokines, and activating effective cellular and humoral immune responses. BioVenic offers custom adjuvant combination services for veterinary vaccines. Building on previous research and adjuvant combinations, we adjust the components to help you develop the most suitable combination for your specific antigen.
- Adjuvants in the category of antigen delivery can be combined with immunostimulants or targeting molecules to enhance the antigen's targeting and prolong its presence, inducing effective and long-lasting immune responses and memory antibodies.
- Complex adjuvants composed of multiple immunostimulants that target various specific pattern recognition receptors can provide a broad spectrum of immune responses.
Assessment Services
BioVenic provides comprehensive in vitro and in vivo assessment services for your veterinary vaccine adjuvants. We ensure the addition of adjuvants to your veterinary vaccine is safe and beneficial by directly comparing the immune response with and without adjuvants and determining whether the inclusion of adjuvants causes adverse reactions in animal organisms.
Quality Control
BioVenic enforces strict quality control throughout the entire development process of veterinary vaccine adjuvants, with a particular focus on batch consistency and stability, both of which directly impact the quality, safety, and efficacy of the vaccines.
| Batch Consistency | Assessments of physical properties, chemical characteristics, and biological activity. |
| Stability |
Tests under various temperature and humidity conditions. The research platform for studying antigen-adjuvant interactions. |
Why Choose Us?
BioVenic's dedicated professionals are well-versed in various types of adjuvants, their properties, and how best to apply them in veterinary vaccine formulations.
We offer customized solutions for veterinary vaccine adjuvants to meet your specific needs, including personalized choices for adjuvant type, concentration, and combinations.
BioVenic has established a technical platform for adjuvant safety and efficacy assessments, enabling you to confirm the safety and enhancing effects of adjuvants in veterinary vaccines.
With a stringent quality control system in place, we ensure the consistency of adjuvants across different batches.
Adjuvants play an indispensable role in veterinary vaccine development, enhancing efficacy, and stability, and reducing antigen dosage while catering to the unique needs of various animal species. BioVenic provides professional adjuvant development services, dedicated to assisting veterinary vaccine development. We also offer high-quality custom adjuvant combination services to meet your individual needs. Please contact us for animal health and immune protection!
References
- Burakova, Yulia, et al. "Adjuvants for animal vaccines." Viral immunology 31.1 (2018): 11-22.
- Nooraei, Soren, et al. "Immunogenicity of Different Types of Adjuvants and Nano-Adjuvants in Veterinary Vaccines: A Comprehensive Review." Vaccines 11.2 (2023): 453.