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Veterinary Vaccine Formulation Development by Administration Route
Although veterinary vaccines have been in use for a long time, infectious diseases still remain a significant cause of animal illnesses and even fatalities. Many factors can affect the vaccine's ability to provide protective immunity to animals. In addition to the antigenic component, which serves as the primary and active ingredient of the vaccine, administration routes also impact the transport of antigens and adjuvants, the sites of antibody protection, and the potential for local and systemic inflammation. BioVenic offers administration route optimization services, aiming to find the best methods for administering veterinary vaccines through adjustments in the vaccination process and comprehensive experimental assessments.
Types of Common Administration Routes for Animals
BioVenic offers comprehensive administration route optimization services to meet the unique needs of different animal species, whether they are terrestrial or aquatic. Considering factors such as animal welfare, vaccination efficiency, and storage stability, each route is meticulously designed to optimize animal sensation, enhance vaccination effectiveness, and ensure proper storage. The table below lists the main administration routes of veterinary vaccines.
| Types | Modes of administration | Storage conditions | Pain sensory | Safety |
|---|---|---|---|---|
| Injection |
|
Cold chain | Painful | Poor |
| Transmucosal Immunization |
|
Cold chain | Painless | Good |
|
Immersion for Fishes (Transmucosal Immunization) |
|
Cold chain | Painless | Good |
| Percutaneous Immunization |
|
Room temperature | Painless | Good |
Our Services
Administration Route Optimization
In the process of developing veterinary vaccines, BioVenic offers administration route optimization services. We recognize the crucial importance of selecting the right administration route to ensure optimal vaccine delivery, efficacy, and overall success. we investigate which approach provides the best immunization outcomes. Our goal is to enhance the overall performance of veterinary vaccines by optimizing the administration route.
BioVenic provides a wide range of in vivo and in vitro testing services for assessing different administration routes for veterinary vaccines to ensure their safety, immunogenicity, and efficacy in animals.
| Services | Description |
|---|---|
| Animal Model Experiments | BioVenic offers suitable animal models and designs experimental protocols to assess the protective effects of vaccines against infection or disease. |
| Cell-based Experiments | In vitro experiments are conducted using cell lines to evaluate the impact of vaccines on immune cells, including cell activation, cytokine production, and immune responses. |
| Immunological Analysis | Immunological analyses, such as ELISA, flow cytometry, Western blot, etc., are employed to assess the immunogenicity and antibody levels of vaccines. |
| Biochemical Analysis | Biological markers related to the vaccine and their interaction with the animal organism are examined to understand the stability and activity of the vaccine in an in vitro environment. |
Novel Administration Route Development
- Immersion Immunization Development
BioVenic offers popular immersion vaccination methods in aquaculture, proven to be highly effective against various fish viruses and bacteria. Understanding when juvenile fish develop immune competence is crucial for determining the appropriate vaccination timing.
Compared to intraperitoneal injection vaccines, immersion vaccination requires less labor and poses fewer safety concerns for managers. However, the efficacy of immersion vaccines is still not on par with intraperitoneal injections. To address this challenge, BioVenic provides immersion vaccination development services, employing various innovative technologies to assist in obtaining more effective fish vaccines, including spray methods, high-osmolarity immersion, low-frequency ultrasound delivery, and flushing exposure.
| Spray | Hyperosmotic dip | Low frequency sonophoresis | Flush exposure |
For more information related to aquaculture vaccine formulation development, please click on the link below.
- Percutaneous Immunization Development
Percutaneous immunization for veterinary use is a rising method in recent years, which involves the direct introduction of vaccines or antigens into an animal's body through the surface layer of the skin. Bypassing the subcutaneous and muscular tissues, the vaccine is delivered to the epidermal layer of the skin to induce an immune response, typically using devices like microneedles or patches. BioVenic offers various microneedle designs and assesses their potential for improved immunogenicity, simplicity, cost-effectiveness, acceptability, and safety, allowing you to visually observe the results.
| Solid Microneedle | Hollow Microneedle | Coated Microneedle | Dissolvable Microneedle |
Fig.1 Different types of microneedle vaccines and their working mechanisms. 1
Why Choose Us?
Multiple veterinary vaccine administration routes for parallel comparison and selection.
Accompanied by detailed safety and efficacy assessment assays in target animals.
Establishment of an emerging platform for the development of veterinary administration routes.
Different routes of administration can affect the effectiveness and persistence of immunization. Animal comfort and the site of pathogen-induced disease should also be considered when developing the administration route of veterinary vaccines. BioVenic offers vaccine administration route development services that encompass multiple aspects you need to be mindful of during the veterinary vaccine development process. Please do not hesitate to contact us, we are wholeheartedly committed to serving you with unwavering enthusiasm!
References
- Sheng, Tao, et al. "Microneedle-mediated vaccination: innovation and translation." Advanced Drug Delivery Reviews 179 (2021): 113919.
- D'Amico, Carmine, et al. "Development of vaccine formulations: past, present, and future." Drug delivery and translational research 11 (2021): 353-372.