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Veterinary Vaccine In Vitro Stability Assays
Most veterinary vaccines are large and complex molecular assemblies, highly susceptible to environmental influences. Stability, in the context of veterinary vaccines, generally refers to the ability of a veterinary vaccine to maintain its chemical, physical, microbiological, and biological properties within specified limits throughout its shelf life. BioVenic offers veterinary vaccine in vitro stability assay services to provide you with stability and storage study information for veterinary vaccines, which allows you to determine its shelf life and expiration date under specified packaging and storage conditions during the later stages of development.
Fig.1 Recommended vaccine cold storage arrangements. 1
Our Services
Physical and Chemistry Characterization
BioVenic selects sensitivity indicators for your specific veterinary vaccine samples based on the type of product to ensure that changes occurring during storage, such as the color, pH, viscosity, dosage form, turbidity of solutions and suspensions, powder color, texture, solubility, and the presence of visible particles upon reconstitution, are appropriately monitored and assessed.
Antigen Activity Assays
BioVenic monitors the activity of key antigens in vaccines to ensure that veterinary vaccines remain effective throughout their storage period, ensuring that veterinary vaccines are produced with consistent and stable antigenic activity to provide effective immune protection.
| ELISA |
Quantifying the concentration of antigen in veterinary vaccines. Providing a relative concentration of the antigen and allowing tracking of its consistency from batch to batch. |
| Western Blotting |
Detecting the presence and size of antigens in veterinary vaccines. Ensuring consistency of their structure and morphology. |
Stability Testing Services
BioVenic actively engages in providing in vitro stability assay services for veterinary vaccines. These services involve estimating the stability of veterinary vaccine samples through a combination of real-time, accelerated, and stress testing results, which help assess the stability and shelf life of veterinary vaccines, ensuring they maintain their quality and efficacy under various environmental conditions.
| Real-time Stability Testing | Stored under recommended storage conditions and monitored until it no longer meets product performance specifications. |
| Accelerated Stability Testing |
Stored under conditions higher than the actual storage temperature, typically at 37°C or room temperature. Using these tests to understand how the product performs in the short term under deviations from normal storage conditions, providing supportive data for determining the product's shelf life and storage conditions. |
| Stress Stability Testing | Stored more severe conditions, including high temperature, light exposure, vibration, repeated freeze-thaw cycles, oxidation, and others. |
Why Choose Us?
- Helps identify potential problems with your veterinary vaccine components.
- Develop more reasonable storage and transportation requirements, thereby extending the effective life of veterinary vaccines.
- Ensure quality stability of veterinary vaccines.
Our veterinary vaccine in vitro stability testing services play a crucial role in safeguarding the quality and efficacy of veterinary vaccines and helping reduce batch-to-batch variations, ultimately lowering the production costs of vaccines. BioVenic assists in conducting stability assessments under various environmental conditions, thereby facilitating veterinary vaccine development. Feel free to contact us to collaborate in preserving animal health and controlling disease spread!
Reference
- Pambudi, Nugroho Agung, et al. "Vaccine cold chain management and cold storage technology to address the challenges of vaccination programs." Energy Reports 8 (2022): 955-972.