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Feed ANFs-Alkaloids
Alkaloids are nitrogen-containing compounds naturally found in plants, fungi, bacteria, and animals. They have a wide range of uses in pharmaceuticals. While crucial, alkaloids are toxic to both humans and animals, with toxicity influenced by factors including dosage, exposure duration, and individual characteristics. Mild effects can include nausea, itching, and vomiting, while chronic effects range from paralysis and teratogenicity to fatality. To address the antinutritional impact of alkaloids, a comprehensive research platform has been developed for animal nutrition experts at BioVenic. This platform aids in detecting alkaloid levels and devising feed additives and biological treatments using in vitro and in vivo animal models to mitigate their adverse effects.
Background
Common alkaloids with potential harmful effects on humans and animals encompass glycoalkaloids, ergot alkaloids, purine, pyrrolizidine, quinolizidine, and tropane alkaloids.
Glycoalkaloids
It is a family of chemical compounds derived from alkaloids to which sugar groups are appended. Toxic glycoalkaloids can be found in food plants such as tomato, aubergine, and potato.
Ergot alkaloids
Produced by fungi like Claviceps spp. and Neotyphodium spp. on grains and grasses, ingestion of ergot-contaminated grains can impact animal feed consumption, growth, and reproductive cycles.
Purine alkaloids
Mainly encompass caffeine and theobromine, present in plants like tea, coffee, cacao, and maté.
Pyrrolizidine alkaloids
Found in plants from genera such as Senecio, Crotalaria, Heliotropium, Echium, Tirchodesma, and Amsinckia, these alkaloids can lead to liver failure in animals.
Quinolizidine alkaloids
Natural components featuring a quinolizidine structure, often located in leguminous plants and capable of causing birth defects in livestock.
Tropane alkaloids
Naturally occurring in various Solanaceae family plants, these alkaloids are toxic and can have adverse effects on human and animal well-being.
Feed Alkaloids Solutions
Given the adverse effects of alkaloids on animals, monitoring their presence in feed and devising appropriate feed additives or biological treatments are crucial to safeguard animal health and growth performance. Our tailored feed alkaloid solutions provide analytical services for different alkaloid variants, aiding animal nutrition researchers in creating innovative feed additives and bioprocessing techniques to mitigate the risks posed by alkaloids in animal feed.
- Analytical Solutions for Alkaloids
Analyzing alkaloid levels in feed and other samples is vital for assessing feed safety and conducting alkaloid-related animal nutrition studies. Through our comprehensive testing platform, we offer Feed Anti-Nutritional Factor (ANF) Analysis services encompassing alkaloid extraction, sample purification, and alkaloid analysis across various sample types. Tailoring our assays to the specific sample and alkaloid types involved, we facilitate diverse testing options. Additionally, we assist in developing novel approaches for the swift and precise identification of alkaloids. Common analytical methods for alkaloid analysis include HPLC, GC-MS, ELISA, NIR, and more.
- Development of Feed Additives to Counteract Alkaloids
Alkaloids present in animal feed can have detrimental effects on animal growth and well-being. Introducing suitable feed additives offers a viable approach to enhance animal growth performance and mitigate the harmful impacts of toxic alkaloids on animal health. Our integrated platform combines feed testing, animal nutritional metabolite analysis services, and a diverse array of animal in vivo and in vitro models. This setup allows us to assess the effectiveness of new feed additives and aid in the development of strategies to minimize the adverse effects of alkaloids in animal feed.
- Biological Approaches for Alkaloids Reduction in Animal Feed
Toxic alkaloids are frequently found as contaminants in feed, and employing biological methods to deactivate them involves treating affected feed with microorganisms or enzymes. Our Feed Biological Processing Development solutions aid in the development of strains capable of breaking down alkaloids and identifying the associated enzymes. Furthermore, we assist in refining and optimizing enzymatic degradation reactions and microbial fermentation processes to enhance the efficiency of alkaloid decomposition. These solutions not only enhance the utilization of contaminated feed but also reduce feed resource wastage.
- Feed Alkaloids-Related Animal Studies
Our animal nutrition and metabolism in vitro and in vivo modeling platform encompasses a wide spectrum of animal species, including livestock, poultry, and companion animals, along with various models for in vitro fermentation, in vitro digestion, and in vivo animal studies. Leveraging these animal models, animal nutrition researchers can assess the impacts of feed additives or bioprocessing techniques. Coupled with our animal nutrition and metabolite analysis platforms, researchers can gauge and evaluate pertinent parameters in animal studies. Additionally, our omics analysis platform facilitates a comprehensive exploration of the effects of feed alkaloids on animals from a high-throughput perspective, encompassing aspects like the microbiome, metabolome, proteome, and more.
Service Workflow of Feed Alkaloids Solution
Why Choose Us?
Our comprehensive testing platform incorporates a range of advanced technologies, enabling accurate and swift detection of alkaloids in feed and diverse animal samples. Moreover, we assist in the development of novel rapid testing products tailored to your specific research requirements.
Our animal research platform offers a diverse selection of animal models to cater to your research objectives. We provide an array of models including in vivo, in vitro digestion, and in vitro fermentation models, among others, to support your research endeavors.
With a highly experienced research team specializing in alkaloids and related animal nutrition studies, we are equipped to address the challenges you face in your research. We offer tailored solutions, products, and services to meet your needs effectively and efficiently.
Given the varied effects of different alkaloids on various animals, BioVenic's solutions harmonize internal and external resources to assist animal nutrition researchers in alkaloid detection, conducting alkaloid-related animal studies, and developing feed additives or bioprocessing methods to enhance the utilization of alkaloid-contaminated feed. If our Feed ANFs-Alkaloids solution piques your interest, please contact us. We are eager to understand your research requirements better and provide you with a fitting solution.